Eric S Goetzman
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Explore the profile of Eric S Goetzman including associated specialties, affiliations and a list of published articles.
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61
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Recent Articles
1.
Richert A, Zhang Y, Bharathi S, Hernandez A, Dodatko T, Bons J, et al.
bioRxiv
. 2025 Feb;
PMID: 39990440
Glutaric aciduria type-1 (GA1) is an inherited mitochondrial neurometabolic disorder with a poorly understood pathogenesis and unmet medical needs. GA1 can be diagnosed via its hallmark biochemical signature consisting of...
2.
Chiba T, Oda A, Zhang Y, Pfister K, Bons J, Bharathi S, et al.
JCI Insight
. 2025 Feb;
PMID: 39932791
The renal tubular epithelial cells (RTECs) are particularly vulnerable to acute kidney injury (AKI). While fatty acids are the preferred energy source for RTECs via fatty acid oxidation (FAO), FAO-mediated...
3.
Singh S, Bruder A, Costa R, Alves J, Bharathi S, Goetzman E, et al.
J Am Heart Assoc
. 2025 Feb;
14(3):e037640.
PMID: 39895524
Background: The complex interplay between vascular contractility and mitochondrial function is central to cardiovascular disease. The progranulin gene () encodes glycoprotein PGRN (progranulin), a ubiquitous molecule with known anti-inflammatory property....
4.
Zhang Y, Zhang B, Bharathi S, Bons J, Rose J, Shah S, et al.
Biomolecules
. 2025 Jan;
14(12.
PMID: 39766215
Lysine succinylation, and its reversal by sirtuin-5 (SIRT5), is known to modulate mitochondrial fatty acid β-oxidation (FAO). We recently showed that feeding mice dodecanedioic acid, a 12-carbon dicarboxylic acid (DC)...
5.
Chiba T, Oda A, Zhang Y, Bons J, Bharathi S, Pfister K, et al.
bioRxiv
. 2024 Nov;
PMID: 39484612
Proximal tubular epithelial cells (PTECs) are particularly vulnerable to acute kidney injury (AKI). While fatty acids are the preferred energy source for PTECs via fatty acid oxidation (FAO), FAO-mediated H...
6.
Schmidt A, Bharathi S, Solo K, Bons J, Rose J, Schilling B, et al.
Biomolecules
. 2024 Sep;
14(9).
PMID: 39334926
Sirtuin-2 (Sirt2), an NAD+-dependent lysine deacylase enzyme, has previously been implicated as a regulator of glucose metabolism, but the specific mechanisms remain poorly defined. Here, we observed that males, but...
7.
Ghosh S, Sharma R, Bammidi S, Koontz V, Nemani M, Yazdankhah M, et al.
Nat Commun
. 2024 Jul;
15(1):6150.
PMID: 39034314
Non-neovascular or dry age-related macular degeneration (AMD) is a multi-factorial disease with degeneration of the aging retinal-pigmented epithelium (RPE). Lysosomes play a crucial role in RPE health via phagocytosis and...
8.
Sims-Lucas S, Goetzman E, Kleyman T
J Clin Invest
. 2024 Jul;
134(13).
PMID: 38949023
Cystic fibrosis is a debilitating disease characterized by a poor medical prognosis due to devastating lung injury. Recent medical advances targeting the major genetic mutation ΔF508 of the cystic fibrosis...
9.
Goetzman E, Zhang B, Zhang Y, Bharathi S, Bons J, Rose J, et al.
J Clin Invest
. 2024 Apr;
134(12).
PMID: 38687608
Dicarboxylic fatty acids are generated in the liver and kidney in a minor pathway called fatty acid ω-oxidation. The effects of consuming dicarboxylic fatty acids as an alternative source of...
10.
Silva Barbosa A, Pfister K, Chiba T, Bons J, Rose J, Burton J, et al.
J Am Soc Nephrol
. 2023 Dec;
35(2):135-148.
PMID: 38044490
Significance Statement: In this study, we demonstrate that a common, low-cost compound known as octanedioic acid (DC 8 ) can protect mice from kidney damage typically caused by ischemia-reperfusion injury...