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Sinem Karaman

Explore the profile of Sinem Karaman including associated specialties, affiliations and a list of published articles. Areas
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Articles 45
Citations 2945
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Recent Articles
11.
Clement C, DAlessandro A, Thangaswamy S, Chalmers S, Furtado R, Spada S, et al.
Nat Commun . 2021 Jul; 12(1):4447. PMID: 34290243
Tryptophan catabolism is a major metabolic pathway utilized by several professional and non-professional antigen presenting cells to maintain immunological tolerance. Here we report that 3-hydroxy-L-kynurenamine (3-HKA) is a biogenic amine...
12.
Paavonsalo S, Hariharan S, Lackman M, Karaman S
Cells . 2020 Dec; 9(12). PMID: 33327460
Obesity and its comorbidities like diabetes, hypertension and other cardiovascular disorders are the leading causes of death and disability worldwide. Metabolic diseases cause vascular dysfunction and loss of capillaries termed...
13.
Yoon S, Dieterich L, Karaman S, Proulx S, Bachmann S, Sciaroni C, et al.
PLoS One . 2019 Jul; 14(7):e0220341. PMID: 31344105
The lymphatic vascular system plays important roles in the control of tissue fluid homeostasis and immune responses. While VEGF-A-induced angiogenesis promotes hair follicle (HF) growth, the potential role of lymphatic...
14.
Le Joncour V, Karaman S, Laakkonen P
J Vis Exp . 2019 May; (146). PMID: 31058900
Highly selective by nature, the blood-brain barrier (BBB) is essential for the brain homeostasis in physiological conditions. However, in the context of brain tumors, the molecular selectivity of BBB also...
15.
Schwager S, Renner S, Hemmerle T, Karaman S, Proulx S, Fetz R, et al.
JCI Insight . 2018 Dec; 3(23). PMID: 30518687
VEGF-C is an important mediator of lymphangiogenesis and has been shown to alleviate chronic inflammation in a variety of disease models. In this study, we investigated whether targeted delivery of...
16.
Karaman S, Nurmi H, Antila S, Alitalo K
Methods Mol Biol . 2018 Sep; 1846:291-300. PMID: 30242767
The lymphatic vessels can be selectively stimulated to grow in adult mice, rats and pigs by application of viral vectors expressing the lymphangiogenic factors VEGF-C or VEGF-D. Vice versa, lymphangiogenesis...
17.
Karaman S, Leppanen V, Alitalo K
Development . 2018 Jul; 145(14). PMID: 30030240
Vascular endothelial growth factors (VEGFs) are best known for their involvement in orchestrating the development and maintenance of the blood and lymphatic vascular systems. VEGFs are secreted by a variety...
18.
Roudnicky F, Yoon S, Poghosyan S, Schwager S, Poyet C, Vella G, et al.
Oncogene . 2018 Feb; 37(19):2573-2585. PMID: 29467494
Thrombospondin-2 (TSP2) is an anti-angiogenic matricellular protein that inhibits tumor growth and angiogenesis. Tumor-associated blood vascular endothelial cells (BECs) were isolated from human invasive bladder cancers and from matched normal...
19.
Antila S, Karaman S, Nurmi H, Airavaara M, Voutilainen M, Mathivet T, et al.
J Exp Med . 2017 Nov; 214(12):3645-3667. PMID: 29141865
The recent discovery of meningeal lymphatic vessels (LVs) has raised interest in their possible involvement in neuropathological processes, yet little is known about their development or maintenance. We show here...
20.
Vaahtomeri K, Karaman S, Makinen T, Alitalo K
Genes Dev . 2017 Sep; 31(16):1615-1634. PMID: 28947496
Lymphatic vessels are important for tissue fluid homeostasis, lipid absorption, and immune cell trafficking and are involved in the pathogenesis of several human diseases. The mechanisms by which the lymphatic...