Sinem Karaman
Overview
Explore the profile of Sinem Karaman including associated specialties, affiliations and a list of published articles.
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45
Citations
2945
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Recent Articles
21.
Karaman S, Alitalo K
Dev Cell
. 2017 Aug;
42(3):205-207.
PMID: 28787586
Using an in vivo reporter for lymphangiogenesis, a recent study in Nature from Olmeda et al. (2017) describes a new subset of melanomas that induce systemic pre-conditioning of distant organs...
22.
Nitschke M, Bell A, Karaman S, Amouzgar M, Rutkowski J, Scherer P, et al.
Am J Pathol
. 2017 Jul;
187(9):1984-1997.
PMID: 28683257
Chylous pleural effusion (chylothorax) frequently accompanies lymphatic vessel malformations and other conditions with lymphatic defects. Although retrograde flow of chyle from the thoracic duct is considered a potential mechanism underlying...
23.
Gousopoulos E, Proulx S, Bachmann S, Dieterich L, Scholl J, Karaman S, et al.
J Invest Dermatol
. 2017 May;
137(9):1995-2004.
PMID: 28526302
Secondary lymphedema is a common complication after cancer treatment, but the pathomechanisms underlying the disease remain unclear. Using a mouse tail lymphedema model, we found an increase in local and...
24.
25.
Gousopoulos E, Karaman S, Proulx S, Leu K, Buschle D, Detmar M
Eur Surg Res
. 2017 Mar;
58(3-4):180-192.
PMID: 28301852
Background: Lymphoedema represents the cardinal manifestation of lymphatic dysfunction and is associated with expansion of the adipose tissue in the affected limb. In mice, high-fat diet (HFD)-induced obesity was associated...
26.
Heinolainen K, Karaman S, DAmico G, Tammela T, Sormunen R, Eklund L, et al.
Circ Res
. 2017 Mar;
120(9):1414-1425.
PMID: 28298294
Rationale: Vascular endothelial growth factor (VEGF) is the main driver of angiogenesis and vascular permeability via VEGF receptor 2 (VEGFR2), whereas lymphangiogenesis signals are transduced by VEGFC/D via VEGFR3. VEGFR3...
27.
Karaman S, Hollmen M, Yoon S, Alkan H, Alitalo K, Wolfrum C, et al.
Sci Rep
. 2016 Aug;
6:31566.
PMID: 27511834
Obesity comprises great risks for human health, contributing to the development of other diseases such as metabolic syndrome, type 2 diabetes and cardiovascular disease. Previously, obese patients were found to...
28.
Ochsenbein A, Karaman S, Proulx S, Goldmann R, Chittazhathu J, Dasargyri A, et al.
Angiogenesis
. 2016 Jul;
19(4):513-24.
PMID: 27464987
Lymphatic vessels play important roles in fluid drainage and in immune responses, as well as in pathological processes including cancer progression and inflammation. While the molecular regulation of the earliest...
29.
Hollmen M, Karaman S, Schwager S, Lisibach A, Christiansen A, Maksimow M, et al.
Oncoimmunology
. 2016 May;
5(3):e1115177.
PMID: 27141367
Tumor-associated macrophages (TAMs) have been implicated in the promotion of breast cancer growth and metastasis, and a strong infiltration by TAMs has been associated with estrogen receptor (ER)-negative tumors and...
30.
Escobedo N, Proulx S, Karaman S, Dillard M, Johnson N, Detmar M, et al.
JCI Insight
. 2016 Mar;
1(2).
PMID: 26973883
heterozygous mice have a defective lymphatic vasculature and develop late-onset obesity. Chyle abnormally leaks from those vessels, accumulates in the surrounding tissues, and causes an increase in adipose tissue. We...