Simone Picelli
Overview
Explore the profile of Simone Picelli including associated specialties, affiliations and a list of published articles.
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37
Citations
6683
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Recent Articles
1.
Muller A, Sullivan J, Schwarzer W, Wang M, Park-Windhol C, Hasler P, et al.
Nat Med
. 2025 Jan;
31(2):490-501.
PMID: 39779923
Stargardt disease is a currently untreatable, inherited neurodegenerative disease that leads to macular degeneration and blindness due to loss-of-function mutations in the ABCA4 gene. We have designed a dual adeno-associated...
2.
Dwivedi A, Mahesh A, Sanfeliu A, Larkin J, Siwicki R, Sweeney K, et al.
JCI Insight
. 2024 Nov;
10(1.
PMID: 39541170
The availability and integration of electrophysiological and molecular data from the living brain is critical in understanding and diagnosing complex human disease. Intracranial stereo electroencephalography (SEEG) electrodes used for identifying...
3.
Wahle P, Brancati G, Harmel C, He Z, Gut G, Del Castillo J, et al.
Nat Biotechnol
. 2023 May;
41(12):1765-1775.
PMID: 37156914
Organoids generated from human pluripotent stem cells provide experimental systems to study development and disease, but quantitative measurements across different spatial scales and molecular modalities are lacking. In this study,...
4.
Munz M, Bharioke A, Kosche G, Moreno-Juan V, Brignall A, Rodrigues T, et al.
Cell
. 2023 Apr;
186(9):1930-1949.e31.
PMID: 37071993
Cortical circuits are composed predominantly of pyramidal-to-pyramidal neuron connections, yet their assembly during embryonic development is not well understood. We show that mouse embryonic Rbp4-Cre cortical neurons, transcriptomically closest to...
5.
Hahaut V, Picelli S
Methods Mol Biol
. 2022 Dec;
2584:123-164.
PMID: 36495447
The single-cell RNA-sequencing (scRNA-seq) field has evolved tremendously since the first paper was published back in 2009 (Tang et al. Nat Methods 6:377-382, 2009). While the first methods analyzed just...
6.
DAlise A, Brasu N, De Intinis C, Leoni G, Russo V, Langone F, et al.
Sci Transl Med
. 2022 Aug;
14(657):eabo7604.
PMID: 35947675
Upon chronic antigen exposure, CD8 T cells become exhausted, acquiring a dysfunctional state correlated with the inability to control infection or tumor progression. In contrast, stem-like CD8 T progenitors maintain...
7.
Hahaut V, Pavlinic D, Carbone W, Schuierer S, Balmer P, Quinodoz M, et al.
Nat Biotechnol
. 2022 May;
40(10):1447-1451.
PMID: 35637419
We present FLASH-seq (FS), a full-length single-cell RNA sequencing (scRNA-seq) method with increased sensitivity and reduced hands-on time compared to Smart-seq3. The entire FS protocol can be performed in ~4.5 ...
8.
Mold J, Modolo L, Hard J, Zamboni M, Larsson A, Stenudd M, et al.
Cell Rep
. 2021 May;
35(8):109174.
PMID: 34038736
The CD8 T cell response to an antigen is composed of many T cell clones with unique T cell receptors, together forming a heterogeneous repertoire of effector and memory cells....
9.
Cowan C, Renner M, De Gennaro M, Gross-Scherf B, Goldblum D, Hou Y, et al.
Cell
. 2020 Sep;
182(6):1623-1640.e34.
PMID: 32946783
Human organoids recapitulating the cell-type diversity and function of their target organ are valuable for basic and translational research. We developed light-sensitive human retinal organoids with multiple nuclear and synaptic...
10.
Cirovic B, de Bree L, Groh L, Blok B, Chan J, van der Velden W, et al.
Cell Host Microbe
. 2020 Jun;
28(2):322-334.e5.
PMID: 32544459
Induction of trained immunity by Bacille-Calmette-Guérin (BCG) vaccination mediates beneficial heterologous effects, but the mechanisms underlying its persistence and magnitude remain elusive. In this study, we show that BCG vaccination...