» Authors » Simon R Foster

Simon R Foster

Explore the profile of Simon R Foster including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 30
Citations 594
Followers 0
Related Specialties
Top 10 Co-Authors
Published In
Affiliations
Soon will be listed here.
Recent Articles
1.
Foster S, Hudson J
Nat Cardiovasc Res . 2024 Oct; 3(10):1181-1183. PMID: 39402205
No abstract available.
2.
Bloxham C, Hulme K, Fierro F, Fercher C, Pegg C, OBrien S, et al.
Biochem Pharmacol . 2023 Nov; 219:115932. PMID: 37989413
Bitter taste receptors (T2R) are a subfamily of G protein-coupled receptors that enable humans to detect aversive and toxic substances. The ability to discern bitter compounds varies between individuals and...
3.
Voges H, Foster S, Reynolds L, Parker B, Devilee L, Quaife-Ryan G, et al.
Cell Rep . 2023 Apr; 42(5):112322. PMID: 37105170
Crosstalk between cardiac cells is critical for heart performance. Here we show that vascular cells within human cardiac organoids (hCOs) enhance their maturation, force of contraction, and utility in disease...
4.
Pokhrel R, Morgan A, Robinson H, Stone M, Foster S
Br J Pharmacol . 2023 Feb; 181(14):2359-2370. PMID: 36772927
G protein-coupled receptor (GPCR) activation initiates signalling via a complex network of intracellular effectors that combine to produce diverse cellular and tissue responses. Although we have an advanced understanding of...
5.
Pallareti L, Rath T, Trapkov B, Tsonkov T, Nielsen A, Harpsoe K, et al.
Eur J Pharmacol . 2023 Feb; 943:175553. PMID: 36736525
The orphan G protein-coupled receptor GPR139 is predominantly expressed in the central nervous system and has attracted considerable interest as a therapeutic target. However, the biological role of this receptor...
6.
Bhusal R, Aryal P, Devkota S, Pokhrel R, Gunzburg M, Foster S, et al.
Proc Natl Acad Sci U S A . 2022 Feb; 119(9). PMID: 35217625
As natural chemokine inhibitors, evasin proteins produced in tick saliva are potential therapeutic agents for numerous inflammatory diseases. Engineering evasins to block the desired chemokines and avoid off-target side effects...
7.
Wang S, Foster S, Sanchez J, Corcilius L, Larance M, Canals M, et al.
ACS Chem Biol . 2021 May; 16(6):973-981. PMID: 33988967
Chemokines are secreted proteins that regulate leukocyte migration during inflammatory responses by signaling through chemokine receptors. Full length CC chemokine ligand 14, CCL14(1-74), is a weak agonist for the chemokine...
8.
Mills R, Humphrey S, Fortuna P, Lor M, Foster S, Quaife-Ryan G, et al.
Cell . 2021 Apr; 184(8):2167-2182.e22. PMID: 33811809
Cardiac injury and dysfunction occur in COVID-19 patients and increase the risk of mortality. Causes are ill defined but could be through direct cardiac infection and/or inflammation-induced dysfunction. To identify...
9.
Arsova A, Moller T, Hellyer S, Vedel L, Foster S, Hansen J, et al.
Mol Pharmacol . 2021 Feb; 99(5):328-341. PMID: 33602724
Positive allosteric modulation of metabotropic glutamate subtype 5 (mGlu) receptor has emerged as a potential new therapeutic strategy for the treatment of schizophrenia and cognitive impairments. However, positive allosteric modulator...
10.
Franck C, Foster S, Johansen-Leete J, Chowdhury S, Cielesh M, Bhusal R, et al.
Proc Natl Acad Sci U S A . 2020 May; 117(23):12657-12664. PMID: 32461364
Blood-feeding arthropods produce antiinflammatory salivary proteins called evasins that function through inhibition of chemokine-receptor signaling in the host. Herein, we show that the evasin ACA-01 from the tick can be...