Simon J Tavernier
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Explore the profile of Simon J Tavernier including associated specialties, affiliations and a list of published articles.
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32
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1035
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Recent Articles
1.
Duthoo E, Beyls E, Backers L, Gudjonsson T, Huang P, Jonckheere L, et al.
J Exp Med
. 2025 Mar;
222(5).
PMID: 40029331
Ataxia telangiectasia and Rad3-related (ATR) kinase and its interacting protein ATRIP orchestrate the replication stress response. Homozygous splice variants in the ATRIP gene, resulting in ATRIP deficiency, were identified in...
2.
Beyls E, Duthoo E, Backers L, Claes K, De Bruyne M, Pottie L, et al.
J Clin Immunol
. 2025 Feb;
45(1):75.
PMID: 39945898
Human inborn errors of immunity (IEI) represent a diverse group of genetic disorders affecting the innate and/or adaptive immune system. Some IEI entities comprise defects in DNA repair factors, resulting...
3.
Ouedraogo L, Deng L, Ouattara C, Compaore A, Ouedraogo M, Argaw A, et al.
Nutrients
. 2024 Dec;
16(23.
PMID: 39683635
: Small vulnerable newborns (SVNs), including those born preterm, small for gestational age, or with low birth weight, are at higher risk of neonatal mortality and long-term health complications. Early...
4.
Hoste L, Meertens B, Ogunjimi B, Sabato V, Guerti K, van der Hilst J, et al.
Inflammation
. 2024 Nov;
PMID: 39528768
Patients with non-infectious systemic inflammation may suffer from one of many diseases, including hyperinflammation (HI), autoinflammatory disorders (AID), and systemic autoimmune disease (AI). Despite their clinical overlap, the pathophysiology and...
5.
Tulling A, Holierhoek M, Jansen-Hoogendijk A, Hoste L, Haerynck F, Tavernier S, et al.
Clin Immunol
. 2024 May;
264:110252.
PMID: 38744408
Children with Multisystem Inflammatory Syndrome in Children (MIS-C) can present with thrombocytopenia, which is a key feature of hemophagocytic lymphohistiocytosis (HLH). We hypothesized that thrombocytopenic MIS-C patients have more features...
6.
Cools M, Grijp C, Neirinck J, Tavernier S, Schelstraete P, Van de Velde J, et al.
Eur J Endocrinol
. 2023 Dec;
190(1):34-43.
PMID: 38128121
Objective: NR5A1 is a key regulator of sex differentiation and has been implicated in spleen development through transcription activation of TLX1. Concerns exist about hypo- or asplenism in individuals who...
7.
Karla A, Pinard A, Boerio M, Hemelsoet D, Tavernier S, De Pauw M, et al.
Am J Med Genet A
. 2023 Dec;
194(4):e63486.
PMID: 38041217
Aicardi-Goutières syndrome (AGS) is an autosomal recessive inflammatory syndrome that manifests as an early-onset encephalopathy with both neurologic and extraneurologic clinical findings. AGS has been associated with pathogenic variants in...
8.
Van Damme K, Hoste L, Declercq J, De Leeuw E, Maes B, Martens L, et al.
Sci Transl Med
. 2023 Aug;
15(710):eadi0252.
PMID: 37611083
Improvements in COVID-19 treatments, especially for the critically ill, require deeper understanding of the mechanisms driving disease pathology. The complement system is not only a crucial component of innate host...
9.
Bosteels V, Marechal S, De Nolf C, Rennen S, Maelfait J, Tavernier S, et al.
Sci Immunol
. 2023 May;
8(83):eadd3955.
PMID: 37172103
Dendritic cells (DCs) mature in an immunogenic or tolerogenic manner depending on the context in which an antigen is perceived, preserving the balance between immunity and tolerance. Whereas the pathways...
10.
Bosteels C, Van Damme K, De Leeuw E, Declercq J, Maes B, Bosteels V, et al.
Cell Rep Med
. 2022 Dec;
3(12):100833.
PMID: 36459994
GM-CSF promotes myelopoiesis and inflammation, and GM-CSF blockade is being evaluated as a treatment for COVID-19-associated hyperinflammation. Alveolar GM-CSF is, however, required for monocytes to differentiate into alveolar macrophages (AMs)...