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Shuichi Nagashima

Explore the profile of Shuichi Nagashima including associated specialties, affiliations and a list of published articles. Areas
Snapshot
Articles 36
Citations 419
Followers 0
Related Specialties
Endocrinology
Biochemistry
General Medicine
Top 10 Co-Authors
Shun Ishibashi
Manabu Takahashi
Hiroaki Yagyu
Ken Ebihara
Daisuke Yamamuro
Kenta Okada
Jun-Ichi Osuga
Tetsuji Wakabayashi
Akihito Takei
Shoko Takei
Published In
J Lipid Res
J Atheroscler Thromb
Arterioscler Thromb Vasc Biol
Endocr J
J Clin Lipidol
Affiliations
Soon will be listed here.
Recent Articles
11.
Normal plasma apoB48 despite the virtual absence of apoB100 in a compound heterozygote with novel mutations in the MTTP gene
Takahashi M, Ozaki N, Nagashima S, Wakabayashi T, Iwamoto S, Ishibashi S
J Clin Lipidol . 2021 May; 15(4):569-573. PMID: 34052173
"Normotriglyceridemic abetalipoproteinemia (ABL)" was originally described as a clinical entity distinct from either ABL or hypobetalipoproteinemia. Subsequent studies identified mutations in APOB gene which encoded truncated apoB longer than apoB48....
12.
A case of insulinoma with hypoglycemia that was better managed with lanreotide than octreotide
Yamaoka K, Nagashima S, Okada N, Sawayama N, Saito S, Takahashi M, et al.
Clin Case Rep . 2021 May; 9(5):e04118. PMID: 34026158
Long-acting somatostatin analogs, including lanreotide slow release (LAN-SR) and octreotide long-acting release (OCT-LAR), can improve hypoglycemia in insulinoma. LAN-SR may be more beneficial in some patients with insulinoma than OCT-LAR.
13.
A novel SOX10 nonsense mutation in a patient with Kallmann syndrome and Waardenburg syndrome
Wakabayashi T, Takei A, Okada N, Shinohara M, Takahashi M, Nagashima S, et al.
Endocrinol Diabetes Metab Case Rep . 2021 Apr; 2021. PMID: 33913437
Summary: The underlying genetic drivers of Kallmann syndrome, a rare genetic disorder characterized by anosmia and hypogonadotropic hypogonadism due to impairment in the development of olfactory axons and in the...
14.
β-Cell-Specific Deletion of HMG-CoA (3-hydroxy-3-methylglutaryl-coenzyme A) Reductase Causes Overt Diabetes due to Reduction of β-Cell Mass and Impaired Insulin Secretion
Takei S, Nagashima S, Takei A, Yamamuro D, Wakabayashi T, Murakami A, et al.
Diabetes . 2020 Aug; 69(11):2352-2363. PMID: 32796082
Inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), statins, which are used to prevent cardiovascular diseases, are associated with a modest increase in the risk of new-onset diabetes. To investigate the role of...
15.
Esterification of 4β-hydroxycholesterol and other oxysterols in human plasma occurs independently of LCAT
Yamamuro D, Yamazaki H, Osuga J, Okada K, Wakabayashi T, Takei A, et al.
J Lipid Res . 2020 Jun; 61(9):1287-1299. PMID: 32561542
The acyltransferase LCAT mediates FA esterification of plasma cholesterol. In vitro studies have shown that LCAT also FA-esterifies several oxysterols, but in vivo evidence is lacking. Here, we measured both...
16.
Peripheral circadian rhythms in the liver and white adipose tissue of mice are attenuated by constant light and restored by time-restricted feeding
Yamamuro D, Takahashi M, Nagashima S, Wakabayashi T, Yamazaki H, Takei A, et al.
PLoS One . 2020 Jun; 15(6):e0234439. PMID: 32530967
Disturbance of circadian rhythms underlies various metabolic diseases. Constant light exposure (LL) is known to disrupt both central and peripheral circadian rhythms. Here, we attempted to determine whether the effects...
17.
Long-term efficacy of the sodium-glucose cotransporter 2 inhibitor, ipragliflozin, in a case of type A insulin resistance syndrome
Nagashima S, Wakabayashi T, Saito N, Takahashi M, Okada K, Ebihara K, et al.
J Diabetes Investig . 2020 Feb; 11(5):1363-1365. PMID: 32100949
Type A insulin resistance (IR) syndrome is a severe IR form caused by insulin receptor (INSR) gene defects. Antidiabetic drugs, including high-dose insulin and insulin-sensitizing agents, often fail to control...
18.
Myeloid HMG-CoA Reductase Determines Adipose Tissue Inflammation, Insulin Resistance, and Hepatic Steatosis in Diet-Induced Obese Mice
Takei A, Nagashima S, Takei S, Yamamuro D, Murakami A, Wakabayashi T, et al.
Diabetes . 2019 Nov; 69(2):158-164. PMID: 31690648
Adipose tissue macrophages (ATMs) are involved in the development of insulin resistance in obesity. We have recently shown that myeloid cell-specific reduction of HMG-CoA reductase ( ), which is the...
19.
Myeloid HMG-CoA (3-Hydroxy-3-Methylglutaryl-Coenzyme A) Reductase Determines Atherosclerosis by Modulating Migration of Macrophages
Sakai K, Nagashima S, Wakabayashi T, Tumenbayar B, Hayakawa H, Hayakawa M, et al.
Arterioscler Thromb Vasc Biol . 2018 Oct; 38(11):2590-2600. PMID: 30354246
Objective- Inhibition of HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase) is atheroprotective primarily by decreasing plasma LDL (low-density lipoprotein)-cholesterol. However, it is unknown whether inhibition of HMGCR in myeloid cells contributes to this...
20.
Inflammasome Activation Aggravates Cutaneous Xanthomatosis and Atherosclerosis in ACAT1 (Acyl-CoA Cholesterol Acyltransferase 1) Deficiency in Bone Marrow
Wakabayashi T, Takahashi M, Yamamuro D, Karasawa T, Takei A, Takei S, et al.
Arterioscler Thromb Vasc Biol . 2018 Oct; 38(11):2576-2589. PMID: 30354239
Objective- ACAT1 (Acyl-CoA cholesterol acyltransferase 1) esterifies cellular free cholesterol, thereby converting macrophages to cholesteryl ester-laden foam cells in atherosclerotic lesions and cutaneous xanthoma. Paradoxically, however, loss of ACAT1 in...