Jun-Ichi Osuga
Overview
Explore the profile of Jun-Ichi Osuga including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
66
Citations
2420
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Yamamuro D, Yamazaki H, Osuga J, Okada K, Wakabayashi T, Takei A, et al.
J Lipid Res
. 2020 Jun;
61(9):1287-1299.
PMID: 32561542
The acyltransferase LCAT mediates FA esterification of plasma cholesterol. In vitro studies have shown that LCAT also FA-esterifies several oxysterols, but in vivo evidence is lacking. Here, we measured both...
2.
Kario K, Okada K, Kato M, Nishizawa M, Yoshida T, Asano T, et al.
Circulation
. 2018 Dec;
139(18):2089-2097.
PMID: 30586745
Background: The risk of cardiovascular disease and mortality in salt-sensitive patients with diabetes mellitus and uncontrolled nocturnal hypertension is high. The SACRA (Sodium-Glucose Cotransporter 2 [SGLT2] Inhibitor and Angiotensin Receptor...
3.
Sakai K, Nagashima S, Wakabayashi T, Tumenbayar B, Hayakawa H, Hayakawa M, et al.
Arterioscler Thromb Vasc Biol
. 2018 Oct;
38(11):2590-2600.
PMID: 30354246
Objective- Inhibition of HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase) is atheroprotective primarily by decreasing plasma LDL (low-density lipoprotein)-cholesterol. However, it is unknown whether inhibition of HMGCR in myeloid cells contributes to this...
4.
Takanashi M, Taira Y, Okazaki S, Takase S, Kimura T, Li C, et al.
J Atheroscler Thromb
. 2017 Apr;
24(11):1105-1116.
PMID: 28413180
Aim: Myriad biological effects of leptin may lead to broad therapeutic applications for various metabolic diseases, including diabetes and its complications; however, in contrast to its anorexic effect, the molecular...
5.
Nagashima S, Yagyu H, Tozawa R, Tazoe F, Takahashi M, Kitamine T, et al.
J Lipid Res
. 2015 Mar;
56(5):998-1005.
PMID: 25755092
Squalene synthase (SS) catalyzes the biosynthesis of squalene, the first specific intermediate in the cholesterol biosynthetic pathway. To test the feasibility of lowering plasma cholesterol by inhibiting hepatic SS, we...
6.
Sekiya M, Yamamuro D, Ohshiro T, Honda A, Takahashi M, Kumagai M, et al.
J Lipid Res
. 2014 Jun;
55(10):2082-92.
PMID: 24891333
An excess of cholesterol and/or oxysterols induces apoptosis in macrophages, contributing to the development of advanced atherosclerotic lesions. In foam cells, these sterols are stored in esterified forms, which are...
7.
Sakai K, Igarashi M, Yamamuro D, Ohshiro T, Nagashima S, Takahashi M, et al.
J Lipid Res
. 2014 May;
55(10):2033-40.
PMID: 24868095
Hydrolysis of intracellular cholesteryl ester (CE) is the rate-limiting step in the efflux of cholesterol from macrophage foam cells. In mouse peritoneal macrophages (MPMs), this process is thought to involve...
8.
Okada K, Kotani K, Yagyu H, Ando A, Osuga J, Ishibashi S
Endocrine
. 2014 Apr;
47(3):962-4.
PMID: 24696097
No abstract available.
9.
Okada K, Yagyu H, Kotani K, Yamazaki H, Ozaki K, Takahashi M, et al.
Endocr J
. 2013 Apr;
60(7):913-22.
PMID: 23574730
Postprandial hyperglycemia and/or hyperlipidemia can contribute to development of atherosclerosis in patients with type 2 diabetes mellitus (T2DM). The objective of this study was to compare the effects of miglitol...
10.
Takase S, Osuga J, Fujita H, Hara K, Sekiya M, Igarashi M, et al.
J Atheroscler Thromb
. 2013 Mar;
20(5):481-93.
PMID: 23470567
Aim: Familial apolipoprotein C-II (apoC-II) deficiency is a rare autosomal recessive disorder with marked hypertriglyceridemia resulting from impaired activation of lipoprotein lipase. In most cases of apoC-II deficiency, causative mutations...