Shoko Takei
Overview
Explore the profile of Shoko Takei including associated specialties, affiliations and a list of published articles.
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Articles
9
Citations
76
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Recent Articles
1.
Takahashi M, Yamamuro D, Wakabayashi T, Takei A, Takei S, Nagashima S, et al.
J Biol Chem
. 2022 Aug;
298(9):102322.
PMID: 35926714
During obesity, tissue macrophages increase in number and become proinflammatory, thereby contributing to metabolic dysfunction. Lipoprotein lipase (LPL), which hydrolyzes triglyceride in lipoproteins, is secreted by macrophages. However, the role...
2.
Isoda M, Ebihara K, Sawayama N, Murakami A, Ebihara C, Shibuya K, et al.
Sci Rep
. 2021 Sep;
11(1):17691.
PMID: 34489483
Leptin is an adipocyte-derived hormone that regulates appetite and energy expenditure via the hypothalamus. Since the majority of obese subjects are leptin resistant, leptin sensitizers, rather than leptin itself, are...
3.
Takei S, Nagashima S, Takei A, Yamamuro D, Wakabayashi T, Murakami A, et al.
Diabetes
. 2020 Aug;
69(11):2352-2363.
PMID: 32796082
Inhibitors of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), statins, which are used to prevent cardiovascular diseases, are associated with a modest increase in the risk of new-onset diabetes. To investigate the role of...
4.
Yamamuro D, Yamazaki H, Osuga J, Okada K, Wakabayashi T, Takei A, et al.
J Lipid Res
. 2020 Jun;
61(9):1287-1299.
PMID: 32561542
The acyltransferase LCAT mediates FA esterification of plasma cholesterol. In vitro studies have shown that LCAT also FA-esterifies several oxysterols, but in vivo evidence is lacking. Here, we measured both...
5.
Yamamuro D, Takahashi M, Nagashima S, Wakabayashi T, Yamazaki H, Takei A, et al.
PLoS One
. 2020 Jun;
15(6):e0234439.
PMID: 32530967
Disturbance of circadian rhythms underlies various metabolic diseases. Constant light exposure (LL) is known to disrupt both central and peripheral circadian rhythms. Here, we attempted to determine whether the effects...
6.
Takei A, Nagashima S, Takei S, Yamamuro D, Murakami A, Wakabayashi T, et al.
Diabetes
. 2019 Nov;
69(2):158-164.
PMID: 31690648
Adipose tissue macrophages (ATMs) are involved in the development of insulin resistance in obesity. We have recently shown that myeloid cell-specific reduction of HMG-CoA reductase ( ), which is the...
7.
Sakai K, Nagashima S, Wakabayashi T, Tumenbayar B, Hayakawa H, Hayakawa M, et al.
Arterioscler Thromb Vasc Biol
. 2018 Oct;
38(11):2590-2600.
PMID: 30354246
Objective- Inhibition of HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase) is atheroprotective primarily by decreasing plasma LDL (low-density lipoprotein)-cholesterol. However, it is unknown whether inhibition of HMGCR in myeloid cells contributes to this...
8.
Wakabayashi T, Takahashi M, Yamamuro D, Karasawa T, Takei A, Takei S, et al.
Arterioscler Thromb Vasc Biol
. 2018 Oct;
38(11):2576-2589.
PMID: 30354239
Objective- ACAT1 (Acyl-CoA cholesterol acyltransferase 1) esterifies cellular free cholesterol, thereby converting macrophages to cholesteryl ester-laden foam cells in atherosclerotic lesions and cutaneous xanthoma. Paradoxically, however, loss of ACAT1 in...
9.
Yamazaki H, Takahashi M, Wakabayashi T, Sakai K, Yamamuro D, Takei A, et al.
J Atheroscler Thromb
. 2018 Oct;
26(3):246-259.
PMID: 30282838
Aim: Acyl-CoA cholesterol acyltransferase 1 (ACAT1) esterifies free cholesterol to cholesteryl esters (CE), which are subsequently hydrolyzed by neutral cholesterol ester hydrolase 1 (NCEH1). The elimination of ACAT1 in vitro...