Shin-Ichi Ikushiro
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Explore the profile of Shin-Ichi Ikushiro including associated specialties, affiliations and a list of published articles.
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Citations
594
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Recent Articles
1.
Ikushiro H, Honda T, Murai Y, Murakami T, Takahashi A, Sawai T, et al.
J Biol Chem
. 2024 Feb;
300(3):105728.
PMID: 38325740
Serine palmitoyltransferase (SPT) catalyzes the pyridoxal-5'-phosphate (PLP)-dependent decarboxylative condensation of l-serine and palmitoyl-CoA to form 3-ketodihydrosphingosine (KDS). Although SPT was shown to synthesize corresponding products from amino acids other than...
2.
Tanaka Y, Okuyama H, Nishikawa M, Ikushiro S, Ikeda M, Ishima Y, et al.
Food Sci Nutr
. 2022 Apr;
10(4):1070-1080.
PMID: 35432956
8-Prenylnaringenin (8-PN), a hop flavonoid, is a promising food substance with health benefits. Compared with nonprenylated naringenin, 8-PN exhibits stronger estrogenic activity and prevents muscle atrophy. Moreover, 8-PN prevents hot...
3.
Yasuda K, Watanabe K, Fukami T, Nakashima S, Ikushiro S, Nakajima M, et al.
Drug Metab Pharmacokinet
. 2021 Jun;
39:100397.
PMID: 34171773
Recently, in addition to carboxylesterases (CESs), we found that arylacetamide deacetylase (AADAC) plays an important role in the metabolism of some clinical drugs. In this study, we screened for food-related...
4.
Yamaga M, Tani H, Nishikawa M, Fukaya K, Ikushiro S, Murota K
Food Funct
. 2021 Mar;
12(6):2520-2530.
PMID: 33688872
Brazilian green propolis (BGP) has chemical compounds from botanical origin that are mainly cinnamic acid derivatives (artepillin C, baccharin, and drupanin) and flavonoids (kaempferide and 6-methoxykaempferide). These compounds are expected...
5.
Kato Y, Tamaki S, Haraguchi K, Ikushiro S, Fujii Y, Ohta C, et al.
J Appl Toxicol
. 2019 Sep;
39(12):1701-1709.
PMID: 31498458
The effects of Kanechlor-500 (KC500) on the levels of serum total thyroxine (T ) and hepatic T in wild-type C57BL/6 (WT) and its transthyretin (TTR)-deficient (TTR-null) mice were comparatively examined....
6.
Sakakibara Y, Katoh M, Imai K, Kondo Y, Asai Y, Ikushiro S, et al.
Biopharm Drug Dispos
. 2016 Apr;
37(5):314-9.
PMID: 27061716
UDP-glucuronosyltransferase (UGT) is an enzyme that catalyses a major phase II reaction in drug metabolism. Glucuronidation occurs mainly in the liver, but UGTs are also expressed in extrahepatic tissues, where...
7.
Inui H, Itoh T, Yamamoto K, Ikushiro S, Sakaki T
Int J Mol Sci
. 2014 Aug;
15(8):14044-57.
PMID: 25123135
Polychlorinated dibenzo-p-dioxins (PCDDs) and coplanar polychlorinated biphenyls (PCBs) contribute to dioxin toxicity in humans and wildlife after bioaccumulation through the food chain from the environment. The authors examined human and...
8.
Watanabe K, Kawai Y, Ikenaka Y, Kawata M, Ikushiro S, Sakaki T, et al.
PLoS One
. 2013 Oct;
8(9):e75689.
PMID: 24098714
Cytochrome P450 (CYP) of chicken and other avian species have been studied primarily with microsomes or characterized by cloning and protein expression. However, the overall existing isoforms in avian CYP1-3...
9.
Uchihashi S, Nishikawa M, Sakaki T, Ikushiro S
Drug Metab Pharmacokinet
. 2012 Oct;
28(3):260-4.
PMID: 23089803
Mouse UDP-glucuronosyltransferase (Ugt) 1a6a and Ugt1a6b share 98% sequence homology, but there have been no reports to date that compare their expression levels or enzymatic activities in serotonin glucuronidation. Thus,...
10.
Kato Y, Tamaki S, Haraguchi K, Ikushiro S, Sekimoto M, Ohta C, et al.
Toxicol Appl Pharmacol
. 2012 Jul;
263(3):323-9.
PMID: 22800508
The relationships between the changes in the levels of serum total thyroxine (T(4)), serum T(4)-transthyretin (TTR) complex, and accumulation of T(4) in tissues by 2,2',4,5,5'-pentachlorobiphenyl (PentaCB) were examined using wild-type...