Raku Shinkyo
Overview
Explore the profile of Raku Shinkyo including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
470
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Recent Articles
1.
Yun C, Fukami K, Shinkyo R, Jiang R
Front Pharmacol
. 2025 Feb;
15:1481937.
PMID: 39911828
Introduction: Plasma protein binding plays a significant role in influencing the pharmacokinetic and pharmacodynamic properties of drugs. This study focuses on examining two pairs of sequence-matched ASOs: phosphorodiamidate morpholino oligomers...
2.
Devereux G, Bula M, Tripp K, FitzGerald R, Eraut N, Alam M, et al.
Clin Pharmacol Drug Dev
. 2024 Jun;
13(9):1071-1081.
PMID: 38924387
AWZ1066S has been developed as a potential treatment for the neglected tropical diseases lymphatic filariasis and onchocerciasis. AWZ1066S targets the Wolbachia bacterial endosymbiont present in the causative nematode parasites. This...
3.
Jiang R, Hooshfar S, Rebecca Eno M, Yun C, Sonego Zimmermann E, Shinkyo R
Curr Drug Metab
. 2023 Apr;
24(7):536-552.
PMID: 37076460
Therapeutic antisense oligonucleotides (ASOs) represent a diverse array of chemically modified singlestranded deoxyribonucleotides that work complementarily to affect their mRNA targets. They vastly differ from conventional small molecules. These newly...
4.
Takahashi M, Miki S, Fujimoto K, Fukuoka K, Matsushita Y, Maida Y, et al.
Cancer Sci
. 2019 May;
110(7):2247-2257.
PMID: 31099446
Glioblastoma is one of the most devastating human malignancies for which a novel efficient treatment is urgently required. This pre-clinical study shows that eribulin, a specific inhibitor of telomerase reverse...
5.
Ando H, Yoshinaga T, Yamamoto W, Asakura K, Uda T, Taniguchi T, et al.
J Pharmacol Toxicol Methods
. 2016 Dec;
84:111-127.
PMID: 27956204
Introduction: Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are anticipated to be a useful tool for conducting proarrhythmia risk assessments of drug candidates. However, a torsadogenic risk prediction paradigm using...
6.
Shinkyo R, Xu L, Tallman K, Cheng Q, Porter N, Guengerich F
J Biol Chem
. 2011 Aug;
286(38):33021-8.
PMID: 21813643
7-Ketocholesterol is a bioactive sterol, a potent competitive inhibitor of cytochrome P450 7A1, and toxic in liver cells. Multiple origins of this compound have been identified, with cholesterol being the...
7.
Shinkyo R, Guengerich F
J Biol Chem
. 2011 Apr;
286(21):18426-33.
PMID: 21471209
If cholesterol is a substrate of P450 3A4, then it follows that it should also be an inhibitor, particularly in light of the high concentrations found in liver. Heme perturbation...
8.
Xiao Y, Shinkyo R, Guengerich F
Drug Metab Dispos
. 2011 Mar;
39(6):944-6.
PMID: 21430234
Cytochrome P450 (P450) 2S1 is one of the orphan P450s without a clear physiological function. Controversy has arisen as to whether it can interact with NADPH-P450 reductase and accept electrons....
9.
Hirosue S, Tazaki M, Hiratsuka N, Yanai S, Kabumoto H, Shinkyo R, et al.
Biochem Biophys Res Commun
. 2011 Mar;
407(1):118-23.
PMID: 21362401
To elucidate functional diversity of cytochrome P450 monooxygenases from the white-rot basidiomycete Phanerochaete chrysosporium (PcCYPs), we conducted a comprehensive functional screening using a wide variety of compounds. A functionomic survey...
10.
Shinkyo R, Guengerich F
J Biol Chem
. 2010 Dec;
286(6):4632-43.
PMID: 21147774
Cytochrome P450 (P450) 7A1 is well known as the cholesterol 7α-hydroxylase, the first enzyme involved in bile acid synthesis from cholesterol. The human enzyme has been reported to have the...