Peter I Mackenzie
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Explore the profile of Peter I Mackenzie including associated specialties, affiliations and a list of published articles.
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112
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2286
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Recent Articles
1.
Meech R, Hu D, Hulin J, Mackenzie P
Expert Opin Drug Metab Toxicol
. 2025 Mar;
PMID: 40081416
Introduction: Sex and gender influence pharmacotherapy outcomes, including adverse drug effects which are nearly twice as common in women. Sex differences in drug responses involve factors as diverse as body...
2.
Hu D, Marri S, Hulin J, Ansaar R, Mackenzie P, McKinnon R, et al.
Drug Metab Dispos
. 2024 Apr;
52(6):526-538.
PMID: 38565302
The human UDP-glucuronosyltransferases (UGTs) have crucial roles in metabolizing and clearing numerous small lipophilic compounds. The locus generates nine UGT1A mRNAs, 65 spliced transcripts, and 34 circular RNAs. In this...
3.
Hu D, Marri S, Hulin J, McKinnon R, Mackenzie P, Meech R
Cancers (Basel)
. 2024 Jan;
16(2).
PMID: 38254842
The locus generates over 60 different alternatively spliced transcripts and 30 circular RNAs. To date, v2 and v3 transcripts are the only variant UGT1A transcripts that have been functionally characterized....
4.
Hu D, Marri S, Hulin J, McKinnon R, Mackenzie P, Meech R
Cancers (Basel)
. 2022 Nov;
14(22).
PMID: 36428799
The human UDP-glycosyltransferase (UGTs) superfamily has a critical role in the metabolism of anticancer drugs and numerous pro/anti-cancer molecules (e.g., steroids, lipids, fatty acids, bile acids and carcinogens). Recent studies...
5.
Miyauchi Y, Kimura A, Sawai M, Fujimoto K, Hirota Y, Tanaka Y, et al.
Front Pharmacol
. 2022 Mar;
13:832931.
PMID: 35295333
Heterologous expression systems are important for analyzing the effects of genetic factors including single nucleotide polymorphisms on the functions of drug-metabolizing enzymes. In this study, we focused on a baculovirus-mammalian...
6.
Hu D, Mackenzie P, Hulin J, McKinnon R, Meech R
Drug Metab Rev
. 2022 Mar;
54(2):120-140.
PMID: 35275773
The human gene superfamily is divided into four subfamilies (, , and ) that encodes 22 functional enzymes. UGTs are critical for the metabolism and clearance of numerous endogenous and...
7.
Hu D, Marri S, Mackenzie P, Hulin J, McKinnon R, Meech R
Cancers (Basel)
. 2021 Sep;
13(17).
PMID: 34503303
The human UDP-glycosyltransferase (UGTs) superfamily has 22 functional enzymes that play a critical role in the metabolism of small lipophilic compounds, including carcinogens, drugs, steroids, lipids, fatty acids, and bile...
8.
Hu D, Mackenzie P, Hulin J, McKinnon R, Meech R
Mol Pharmacol
. 2021 Apr;
99(6):488-503.
PMID: 33824186
The human UDP-glycosyltransferase () gene superfamily generates 22 canonical transcripts coding for functional enzymes and also produces nearly 150 variant UGT transcripts through alternative splicing and intergenic splicing. In the...
9.
The Expression Profiles of ADME Genes in Human Cancers and Their Associations with Clinical Outcomes
Hu D, Mackenzie P, Nair P, McKinnon R, Meech R
Cancers (Basel)
. 2020 Nov;
12(11).
PMID: 33202946
ADME genes are a group of genes that are involved in drug absorption, distribution, metabolism, and excretion (ADME). The expression profiles of ADME genes within tumours is proposed to impact...
10.
Miyauchi Y, Kurohara K, Kimura A, Esaki M, Fujimoto K, Hirota Y, et al.
Drug Metab Pharmacokinet
. 2020 Sep;
35(5):466-474.
PMID: 32883578
UDP-Glucuronosyltransferase (UGT) is a type I membrane protein localized to the endoplasmic reticulum (ER). UGT has a di-lysine motif (KKXX/KXKXX) in its cytoplasmic domain, which is defined as an ER...