Shaked Bergman
Overview
Explore the profile of Shaked Bergman including associated specialties, affiliations and a list of published articles.
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Articles
8
Citations
27
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0
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Recent Articles
1.
Cohen S, Bergman S, Lynn N, Tuller T
Genome Med
. 2024 Dec;
16(1):152.
PMID: 39716183
Background: CRISPR is widely used to silence genes by inducing mutations expected to nullify their expression. While numerous computational tools have been developed to design single-guide RNAs (sgRNAs) with high...
2.
Bergman S, Tuller T
NPJ Syst Biol Appl
. 2024 Sep;
10(1):100.
PMID: 39227603
CRISPR is a precise and effective genome editing technology; but despite several advancements during the last decade, our ability to computationally design gRNAs remains limited. Most predictive models have relatively...
3.
Bergman S, Tuller T
PLoS Comput Biol
. 2024 Jun;
20(6):e1012214.
PMID: 38848440
CRISPR is a gene editing technology which enables precise in-vivo genome editing; but its potential is hampered by its relatively low specificity and sensitivity. Improving CRISPR's on-target and off-target effects...
4.
Arbel-Groissman M, Menuhin-Gruman I, Yehezkeli H, Naki D, Bergman S, Udi Y, et al.
Methods Mol Biol
. 2024 Mar;
2760:371-392.
PMID: 38468099
Genetic engineering has revolutionized our ability to manipulate DNA and engineer organisms for various applications. However, this approach can lead to genomic instability, which can result in unwanted effects such...
5.
Arbel-Groissman M, Menuhin-Gruman I, Naki D, Bergman S, Tuller T
Trends Biotechnol
. 2023 Jul;
41(12):1518-1531.
PMID: 37442714
Synthetic biology has made significant progress in many areas, but a major challenge that has received limited attention is the evolutionary stability of synthetic constructs made of heterologous genes. The...
6.
Menuhin-Gruman I, Arbel M, Amitay N, Sionov K, Naki D, Katzir I, et al.
ACS Synth Biol
. 2021 Dec;
11(3):1142-1151.
PMID: 34928133
Modern synthetic biology procedures rely on the ability to generate stable genetic constructs that keep their functionality over long periods of time. However, maintenance of these constructs requires energy from...
7.
Bergman S, Diament A, Tuller T
Bioinformatics
. 2020 Dec;
36(22-23):5398-5404.
PMID: 33320173
Motivation: MicroRNAs (miRNAs) are short (∼24nt), non-coding RNAs, which downregulate gene expression in many species and physiological processes. Many details regarding the mechanism which governs miRNA-mediated repression continue to elude...
8.
Bergman S, Tuller T
Phys Biol
. 2020 Jan;
17(3):031002.
PMID: 31986496
Messenger RNAs (mRNAs) consist of a coding region (open reading frame (ORF)) and two untranslated regions (UTRs), 5'UTR and 3'UTR. Ribosomes travel along the coding region, translating nucleotide triplets (called...