Shahila Mehboob
Overview
Explore the profile of Shahila Mehboob including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
316
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Recent Articles
1.
Bondoc J, Gutka H, Almutairi M, Patwell R, Rutter M, Wolf N, et al.
Acta Crystallogr F Struct Biol Commun
. 2020 Apr;
76(Pt 4):192-193.
PMID: 32254053
The true identity of the protein found in the crystals reported by Bondoc et al. [(2019), Acta Cryst. F75, 646-651] is given.
2.
Bondoc J, Gutka H, Almutairi M, Patwell R, Rutter M, Wolf N, et al.
Acta Crystallogr F Struct Biol Commun
. 2019 Oct;
75(Pt 10):646-651.
PMID: 31584013
Acyl carrier proteins (ACPs) are important components in fatty-acid biosynthesis in prokaryotes. Rv0100 is predicted to be an essential ACP in Mycobacterium tuberculosis, the pathogen that is the causative agent...
3.
Goswami R, Bondoc J, Wheeler P, Jafari A, Gonzalez T, Mehboob S, et al.
ACS Omega
. 2018 Nov;
3(10):13876-13881.
PMID: 30411052
Inositol monophosphatase (IMPase) is a crucial enzyme for the biosynthesis of phosphatidylinositol, an essential component in mycobacterial cell walls. IMPase A (ImpA) from is a bifunctional enzyme that also functions...
4.
Ren J, Mistry T, Su P, Mehboob S, Demissie R, Fung L, et al.
Bioorg Med Chem Lett
. 2018 May;
28(11):2074-2079.
PMID: 29730028
We have previously reported benzimidazole-based compounds to be potent inhibitors of FabI for Francisella tularensis (FtFabI), making them promising antimicrobial hits. Optically active enantiomers exhibit markedly differing affinities toward FtFabI....
5.
Hevener K, Santarsiero B, Lee H, Jones J, Boci T, Johnson M, et al.
Acta Crystallogr F Struct Biol Commun
. 2018 Feb;
74(Pt 2):105-112.
PMID: 29400320
Enoyl-acyl carrier protein (ACP) reductase II (FabK) is a critical rate-limiting enzyme in the bacterial type II fatty-acid synthesis (FAS II) pathway. FAS II pathway enzymes are markedly disparate from...
6.
Kwon J, Mistry T, Ren J, Johnson M, Mehboob S
Bioorg Med Chem
. 2017 Nov;
26(1):65-76.
PMID: 29162308
S. aureus and A. baumannii are among the ESKAPE pathogens that are increasingly difficult to treat due to the rise in the number of drug resistant strains. Novel therapeutics targeting...
7.
Mistry T, Truong L, Ghosh A, Johnson M, Mehboob S
ACS Infect Dis
. 2016 Oct;
3(1):54-61.
PMID: 27756129
The enoyl-ACP reductase (FabI) enzyme is a well validated target for anti-staphylococcal drug discovery and development. With the goal of finding alternate therapeutics for drug-resistant strains of Staphylococcus aureus, such...
8.
Su P, Tsai C, Mehboob S, Hevener K, Johnson M
J Comput Chem
. 2015 Jul;
36(25):1859-73.
PMID: 26216222
To validate a method for predicting the binding affinities of FabI inhibitors, three implicit solvent methods, MM-PBSA, MM-GBSA, and QM/MM-GBSA were carefully compared using 16 benzimidazole inhibitors in complex with...
9.
McClay K, Mehboob S, Yu J, Santarsiero B, Deng J, Cook J, et al.
AMB Express
. 2015 Jun;
5(1):125.
PMID: 26112315
The I100V isoform of toluene-4-monooxygenase was used to catalyze the oxidative polymerization of anthranil and various indoles under mildly acidic conditions, favoring the production of trimers. Compounds produced in sufficient...
10.
Mehboob S, Song J, Hevener K, Su P, Boci T, Brubaker L, et al.
Bioorg Med Chem Lett
. 2015 Feb;
25(6):1292-6.
PMID: 25677657
Francisella tularensis, the causative agent of tularemia, presents a significant biological threat and is a Category A priority pathogen due to its potential for weaponization. The bacterial FASII pathway is...