Sergey A Krupenko
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Explore the profile of Sergey A Krupenko including associated specialties, affiliations and a list of published articles.
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60
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2831
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Recent Articles
21.
Huang M, Douillet C, Dover E, Zhang C, Beck R, Tejan-Sie A, et al.
Environ Health Perspect
. 2019 Jan;
126(12):127003.
PMID: 30675811
Background: Inorganic arsenic (iAs) is a diabetogen. Interindividual differences in iAs metabolism have been linked to susceptibility to diabetes in iAs-exposed populations. Dietary folate intake has been shown to influence...
22.
Krupenko S, Krupenko N
Adv Exp Med Biol
. 2018 Oct;
1032:127-143.
PMID: 30362096
Epidemiological studies implicate excess ethanol ingestion as a risk factor for several cancers and support the concept of a synergistic effect of chronic alcohol consumption and folate deficiency on carcinogenesis....
23.
Fekry B, Jeffries K, Esmaeilniakooshkghazi A, Szulc Z, Knagge K, Kirchner D, et al.
Nat Commun
. 2018 Oct;
9(1):4149.
PMID: 30297838
Ceramides are important participants of signal transduction, regulating fundamental cellular processes. Here we report the mechanism for activation of p53 tumor suppressor by C-ceramide. C-ceramide tightly binds within the p53...
24.
Khan Q, Pediaditakis P, Malakhau Y, Esmaeilniakooshkghazi A, Ashkavand Z, Sereda V, et al.
PLoS One
. 2018 Jul;
13(7):e0199699.
PMID: 29979702
ALDH1L1 is a folate-metabolizing enzyme abundant in liver and several other tissues. In human cancers and cell lines derived from malignant tumors, the ALDH1L1 gene is commonly silenced through the...
25.
Horita D, Krupenko S
Chem Biol Interact
. 2017 Apr;
276:23-30.
PMID: 28414156
ALDH1L1, a member of the aldehyde dehydrogenase superfamily of enzymes, catalyzes the conversion of 10-formyltetrahydrofolate to tetrahydrofolate and CO. The enzyme is a tetramer of identical subunits, with each subunit...
26.
Ashkavand Z, OFlanagan C, Hennig M, Du X, Hursting S, Krupenko S
Mol Cancer Res
. 2017 Jan;
15(2):189-200.
PMID: 28108628
Implications: Metabolic reprogramming driven by folate restriction represents a therapeutic target for reducing the burden of breast cancer. Mol Cancer Res; 15(2); 189-200. ©2016 AACR.
27.
Fekry B, Jeffries K, Esmaeilniakooshkghazi A, Ogretmen B, Krupenko S, Krupenko N
J Biol Chem
. 2016 Jun;
291(32):16586-96.
PMID: 27302066
Our previous study suggested that ceramide synthase 6 (CerS6), an enzyme in sphingolipid biosynthesis, is regulated by p53: CerS6 was elevated in several cell lines in response to transient expression...
28.
Fekry B, Esmaeilniakooshkghazi A, Krupenko S, Krupenko N
PLoS One
. 2016 Jan;
11(1):e0146618.
PMID: 26783755
We previously reported that ceramide synthase 6 (CerS6) is elevated in response to folate stress in cancer cells, leading to enhanced production of C16-ceramide and apoptosis. Antifolate methotrexate (MTX), a...
29.
Krupenko N, Holmes R, Tsybovsky Y, Krupenko S
Chem Biol Interact
. 2015 Jan;
234:12-7.
PMID: 25549576
Cytosolic and mitochondrial 10-formyltetrahydrofolate dehydrogenases are products of separate genes in vertebrates but only one such gene is present in invertebrates. There is a significant degree of sequence similarity between...
30.
Oleinik N, Helke K, Kistner-Griffin E, Krupenko N, Krupenko S
J Biol Chem
. 2014 Aug;
289(38):26383-26394.
PMID: 25086046
Folate, an important nutrient in the human diet, has been implicated in cancer, but its role in metastasis is not established. We have shown previously that the withdrawal of medium...