Sergey A Krupenko
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Explore the profile of Sergey A Krupenko including associated specialties, affiliations and a list of published articles.
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2831
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Recent Articles
11.
Krupenko N, Sharma J, Fogle H, Pediaditakis P, Strickland K, Du X, et al.
Cancers (Basel)
. 2021 Jul;
13(13).
PMID: 34203215
Cytosolic 10-formyltetrahydrofolate dehydrogenase (ALDH1L1) is commonly downregulated in human cancers through promoter methylation. We proposed that ALDH1L1 loss promotes malignant tumor growth. Here, we investigated the effect of the mouse...
12.
Coleman M, OFlanagan C, Pfeil A, Chen X, Pearce J, Sumner S, et al.
Nutrients
. 2021 Jun;
13(5).
PMID: 34068120
Background: Triple-negative breast cancers (TNBCs), accounting for approximately 15% of breast cancers, lack targeted therapy. A hallmark of cancer is metabolic reprogramming, with one-carbon metabolism essential to many processes altered...
13.
Krupenko S, Sharma J
Cancers (Basel)
. 2021 Apr;
13(7).
PMID: 33918472
We read with interest the article by Lee et al [...].
14.
Krupenko N, Sharma J, Pediaditakis P, Helke K, Hall M, Du X, et al.
Hum Genomics
. 2020 Nov;
14(1):41.
PMID: 33168096
Background: Mitochondrial folate enzyme ALDH1L2 (aldehyde dehydrogenase 1 family member L2) converts 10-formyltetrahydrofolate to tetrahydrofolate and CO simultaneously producing NADPH. We have recently reported that the lack of the enzyme...
15.
Kok D, OFlanagan C, Coleman M, Ashkavand Z, Hursting S, Krupenko S
Biochimie
. 2020 Apr;
173:114-122.
PMID: 32304770
We have previously shown that withdrawal of folic acid led to metabolic reprogramming and a less aggressive phenotype in a mouse cell model of triple-negative breast cancer (TNBC). Herein, we...
16.
Sharma J, Krupenko S
Chem Biol Interact
. 2020 Apr;
324:109091.
PMID: 32283069
Folate and alcohol are dietary factors affecting the risk of cancer development in humans. The interaction between folate status and alcohol consumption in carcinogenesis involves multiple mechanisms. Alcoholism is typically...
17.
Krupenko S, Horita D
Front Genet
. 2019 Nov;
10:1013.
PMID: 31737034
Folate (vitamin B9) is a common name for a group of coenzymes that function as carriers of chemical moieties called one-carbon groups in numerous biochemical reactions. The combination of these...
18.
Krupenko N, Sharma J, Pediaditakis P, Fekry B, Helke K, Du X, et al.
Sci Rep
. 2019 Oct;
9(1):14937.
PMID: 31624291
ALDH1L1 (10-formyltetrahydrofolate dehydrogenase), an enzyme of folate metabolism highly expressed in liver, metabolizes 10-formyltetrahydrofolate to produce tetrahydrofolate (THF). This reaction might have a regulatory function towards reduced folate pools, de...
19.
Sarret C, Ashkavand Z, Paules E, Dorboz I, Pediaditakis P, Sumner S, et al.
NPJ Genom Med
. 2019 Jul;
4:17.
PMID: 31341639
Neuro-ichthyotic syndromes are a group of rare genetic diseases mainly associated with perturbations in lipid metabolism, intracellular vesicle trafficking, or glycoprotein synthesis. Here, we report a patient with a neuro-ichthyotic...
20.
Krupenko S, Krupenko N
Chem Biol Interact
. 2019 Feb;
302:149-155.
PMID: 30794800
ALDH1L1 (cytosolic 10-formyltetrahydrofolate dehydrogenase) is the enzyme in folate metabolism commonly downregulated in human cancers. One of the mechanisms of the enzyme downregulation is methylation of the promoter of the...