Sergey A Krupenko
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Explore the profile of Sergey A Krupenko including associated specialties, affiliations and a list of published articles.
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2831
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Recent Articles
31.
DebRoy S, Kramarenko I, Ghose S, Oleinik N, Krupenko S, Krupenko N
PLoS One
. 2013 Aug;
8(7):e70062.
PMID: 23936142
Glycine N-methyltransferase (GNMT), an abundant cytosolic enzyme, catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to glycine generating S-adenosylhomocysteine and sarcosine (N-methylglycine). This reaction is regulated by 5-methyltetrahydrofolate,...
32.
Hoeferlin L, Fekry B, Ogretmen B, Krupenko S, Krupenko N
J Biol Chem
. 2013 Mar;
288(18):12880-90.
PMID: 23519469
We have investigated the role of ceramide in the cellular adaptation to folate stress induced by Aldh1l1, the enzyme involved in the regulation of folate metabolism. Our previous studies demonstrated...
33.
Tsybovsky Y, Malakhau Y, Strickland K, Krupenko S
Chem Biol Interact
. 2013 Jan;
202(1-3):62-9.
PMID: 23295222
Aldh1l1, also known as 10-formyltetrahydrofolate dehydrogenase (FDH), contains the carboxy-terminal domain (Ct-FDH), which is a structural and functional homolog of aldehyde dehydrogenases (ALDHs). This domain is capable of catalyzing the...
34.
Strickland K, Krupenko N, Krupenko S
Clin Chem Lab Med
. 2012 Dec;
51(3):607-16.
PMID: 23241610
The importance of proper consumption of dietary folate for human health has been highlighted by an extensive number of publications over several decades. Fortification of grain products with folic acid...
35.
Hoeferlin L, Oleinik N, Krupenko N, Krupenko S
Genes Cancer
. 2012 May;
2(9):889-99.
PMID: 22593801
The folate enzyme, FDH (10-formyltetrahydrofolate dehydrogenase, ALDH1L1), a metabolic regulator of proliferation, activates p53-dependent G1 arrest and apoptosis in A549 cells. In the present study, we have demonstrated that FDH-induced...
36.
Oleinik N, Krupenko N, Krupenko S
Genes Cancer
. 2011 Jul;
2(2):130-9.
PMID: 21779486
FDH (10-formyltetrahydrofolate dehydrogenase, the product of the ALDH1L1 gene), a major folate-metabolizing enzyme in the cytosol, is involved in the regulation of cellular proliferation. We have previously demonstrated that FDH...
37.
Carrasco M, Enyedy E, Krupenko N, Krupenko S, Nuti E, Tuccinardi T, et al.
Med Chem
. 2011 May;
7(4):265-74.
PMID: 21568878
A set of hydroxamate derivatives of folic acid and methotrexate (MTX) was synthesized and evaluated for the inhibitory activity against histone deacetylase (HDAC) and dihydrofolate reductase (DHFR), two enzymes overexpressed...
38.
Tsybovsky Y, Krupenko S
J Biol Chem
. 2011 May;
286(26):23357-67.
PMID: 21540484
The C-terminal domain (C(t)-FDH) of 10-formyltetrahydrofolate dehydrogenase (FDH, ALDH1L1) is an NADP(+)-dependent oxidoreductase and a structural and functional homolog of aldehyde dehydrogenases. Here we report the crystal structures of several...
39.
Strickland K, Krupenko N, Dubard M, Hu C, Tsybovsky Y, Krupenko S
Chem Biol Interact
. 2011 Jan;
191(1-3):129-36.
PMID: 21238436
10-Formyltetrahydrofolate dehydrogenase (FDH, ALDH1L1), an abundant cytosolic enzyme of folate metabolism, shares significant sequence similarity with enzymes of the aldehyde dehydrogenase (ALDH) family. The enzyme converts 10-formyltetrahydrofolate (10-fTHF) to tetrahydrofolate...
40.
Strickland K, Holmes R, Oleinik N, Krupenko N, Krupenko S
Chem Biol Interact
. 2011 Jan;
191(1-3):122-8.
PMID: 21215736
Folate coenzymes function as one-carbon group carriers in intracellular metabolic pathways. Folate-dependent reactions are compartmentalized within the cell and are catalyzed by two distinct groups of enzymes, cytosolic and mitochondrial....