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Serena Pasquini

Explore the profile of Serena Pasquini including associated specialties, affiliations and a list of published articles. Areas
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Articles 24
Citations 247
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Recent Articles
11.
Maccioni P, Flore P, Carai M, Mugnaini C, Pasquini S, Corelli F, et al.
Front Psychiatry . 2011 Mar; 1:20. PMID: 21423431
The present study was designed to evaluate (a) alcohol self-administration behavior of selectively bred, Sardinian alcohol-preferring (sP) rats exposed to the so-called "sipper" procedure (characterized by the temporal separation between...
12.
Brogi S, Corelli F, Di Marzo V, Ligresti A, Mugnaini C, Pasquini S, et al.
Eur J Med Chem . 2010 Dec; 46(2):547-55. PMID: 21183257
This paper describes a three-dimensional quantitative structure-selectivity relationships (3D-QSSR) study for selectivity of a series of ligands for cannabinoid CB1 and CB2 receptors. 3D-QSSR exploration was expected to provide design...
13.
Silvestri R, Ligresti A, La Regina G, Piscitelli F, Gatti V, Lavecchia A, et al.
Eur J Med Chem . 2010 Oct; 45(12):5878-86. PMID: 20943290
A series of N-alkyl 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides were synthesized as new ligands of the human recombinant receptor hCB1. n-Alkyl carboxamides brought out different SARs from the branched subgroup. Unsubstituted pyrrole derivatives bearing...
14.
Pasquini S, Ligresti A, Mugnaini C, Semeraro T, Cicione L, De Rosa M, et al.
J Med Chem . 2010 Aug; 53(16):5915-28. PMID: 20718492
A set of quinolone-3-carboxamides 2 bearing diverse substituents at position 1, 3, and 6 of the bicyclic nucleus was prepared. Except for six compounds exhibiting Ki>100 nM, all the quinolone-3-carboxamides...
15.
Cascio M, Bolognini D, Pertwee R, Palazzo E, Corelli F, Pasquini S, et al.
Pharmacol Res . 2009 Dec; 61(4):349-54. PMID: 19961936
We have previously developed quinolone-3-carboxamides with the aim of obtaining new ligands for both cannabinoid receptors, CB1 and CB2. Our preliminary screening led to the identification of cannabinoid receptor ligands...
16.
Pasquini S, Mugnaini C, Brizzi A, Ligresti A, Di Marzo V, Ghiron C, et al.
J Comb Chem . 2009 Aug; 11(5):795-8. PMID: 19694453
No abstract available.
17.
Silvestri R, Ligresti A, La Regina G, Piscitelli F, Gatti V, Brizzi A, et al.
Bioorg Med Chem . 2009 Jul; 17(15):5549-64. PMID: 19595596
New substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides were synthesized by replacing the 2,4-dichlorobenzyl and cyclohexyl moieties at the 3-carboxamide nitrogen of the previously reported CB(1) receptor antagonists/inverse agonists 4 and 5. Several ligands showed...
18.
Mugnaini C, Pasquini S, Corelli F
Curr Med Chem . 2009 May; 16(14):1746-67. PMID: 19442143
Quinolones are among the most common frameworks present in the bioactive molecules and hence represent an attractive starting point for the design of combinatorial libraries. Since 1962 4-quinolone-3-carboxylic acid derivatives...
19.
Brizzi A, Brizzi V, Cascio M, Corelli F, Guida F, Ligresti A, et al.
J Med Chem . 2009 Apr; 52(8):2506-14. PMID: 19331413
Bearing in mind the pharmacophoric requirements of both (-)-trans-Delta(9)-tetrahydrocannabinol (THC) and anandamide (AEA), we designed a novel pharmacophore consisting of both a rigid aromatic backbone and a flexible chain with...
20.
Pasquini S, Botta L, Semeraro T, Mugnaini C, Ligresti A, Palazzo E, et al.
J Med Chem . 2008 Aug; 51(16):5075-84. PMID: 18680276
Quinolone-3-carboxamides 11 bearing at position 5, 6, 7, or 8 diverse substituents such as halides, alkyl, aryl, alkoxy, and aryloxy groups differing in their steric/electronic properties, were prepared. The new...