Claudia Mugnaini
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Explore the profile of Claudia Mugnaini including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Poggialini F, Governa P, Vagaggini C, Maramai S, Lamponi S, Mugnaini C, et al.
Eur J Pharm Sci
. 2025 Mar;
:107066.
PMID: 40064401
The possibility to control the effects of drugs in time and space represents an ideal condition for developing safer and more personalized therapies against different disorders. In this context, photopharmacology...
2.
Maramai S, Mugnaini C, Paolino M, Moriello A, De Petrocellis L, Corelli F, et al.
Molecules
. 2025 Feb;
30(3).
PMID: 39942824
Due to its central role in pain, inflammation, and related disorders, the Transient Receptor Potential (TPR) Vanilloid Type-1 (TRPV1) ion channel represents an attractive target for the development of novel...
3.
Mugnaini C, Brizzi A, Paolino M, Scarselli E, Castelli R, De Candia M, et al.
ACS Chem Neurosci
. 2024 Feb;
15(5):955-971.
PMID: 38372253
Alzheimer's disease (AD) is a neurodegenerative form of dementia characterized by the loss of synapses and a progressive decline in cognitive abilities. Among current treatments for AD, acetylcholinesterase (AChE) inhibitors...
4.
Maccioni P, Mugnaini C, Carai M, Gessa G, Corelli F, Colombo G
Behav Pharmacol
. 2023 Sep;
34(7):437-442.
PMID: 37712580
COR659 is a new compound, the action of which is exerted via a dual mechanism: positive allosteric modulation of the GABAB receptor; antagonism or inverse agonism at the cannabinoid CB1...
5.
Paolino M, De Candia M, Purgatorio R, Catto M, Saletti M, Tondo A, et al.
Molecules
. 2023 Aug;
28(15).
PMID: 37570828
The multitarget therapeutic strategy, as opposed to the more traditional 'one disease-one target-one drug', may hold promise in treating multifactorial neurodegenerative syndromes, such as Alzheimer's disease (AD) and related dementias....
6.
Mugnaini C, Kostrzewa M, Casini M, Kumar P, Catallo V, Allara M, et al.
Molecules
. 2023 Jul;
28(13).
PMID: 37446625
Selective ligands of the CB2 receptor are receiving considerable attention due to their potential as therapeutic agents for a variety of diseases. Recently, 7-hydroxy-5-oxopyrazolo[4,3-]pyridine-6-carboxamide derivatives were shown to act at...
7.
Borgonetti V, Mugnaini C, Corelli F, Galeotti N
Biomedicines
. 2023 Jun;
11(6).
PMID: 37371642
Neuropathic pain is a chronic disabling condition with a 7-10% of prevalence in the general population that is largely undertreated. Available analgesic therapies are poorly effective and are often accompanied...
8.
Romeo I, Brizzi A, Pessina F, Ambrosio F, Aiello F, Belardo C, et al.
J Med Chem
. 2023 May;
66(10):6994-7015.
PMID: 37192374
We describe an -guided rational drug design and the synthesis of the suggested ligands, aimed at improving the TRPV1-ligand binding properties and the potency of -(4-hydroxy-3-methoxybenzyl)-4-(thiophen-2-yl) butanamide , a previously...
9.
Sannio F, Brizzi A, Del Prete R, Avigliano M, Simone T, Pagli C, et al.
Antibiotics (Basel)
. 2022 Dec;
11(12).
PMID: 36551489
The diffusion of antibiotic-resistant, Gram-negative, opportunistic pathogens, an increasingly important global public health issue, causes a significant socioeconomic burden. isolates, despite causing a lower number of infections than Enterobacterales, often...
10.
Brizzi A, Maramai S, Aiello F, Baratto M, Corelli F, Mugnaini C, et al.
Int J Mol Sci
. 2022 Nov;
23(21).
PMID: 36362364
α-Lipoic acid is a sulfur-containing nutrient endowed with pleiotropic actions and a safe biological profile selected to replace the unsaturated alkyl acid of capsaicin with the aim of obtaining lipoic...