Serena Pasquini
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Explore the profile of Serena Pasquini including associated specialties, affiliations and a list of published articles.
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24
Citations
247
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Recent Articles
1.
Guerrini V, De Rosa M, Pasquini S, Mugnaini C, Brizzi A, Cuppone A, et al.
Tuberculosis (Edinb)
. 2013 Mar;
93(4):405-11.
PMID: 23523640
A set of 21 new fluoroquinolones bearing an aromatic or heteroaromatic moiety at C-7 and an alkyl group at N-1 were synthesized based on the lead structure of pirfloxacin and...
2.
Pasquini S, De Rosa M, Ligresti A, Mugnaini C, Brizzi A, Caradonna N, et al.
Eur J Med Chem
. 2012 Oct;
58:30-43.
PMID: 23085772
Within our studies on structure-activity relationships of 4-quinolone-3-carboxamides as cannabinoid ligands, a new series of compounds characterized by a fluoro or phenylthio group at 7-position and different substituents at N1...
3.
Contartese A, Valoti M, Corelli F, Pasquini S, Mugnaini C, Pessina F, et al.
Pharmacol Res
. 2012 Oct;
66(6):555-63.
PMID: 23036353
Cannabinoid CB2 receptor activation has been shown to have many pharmacological but not psychotropic effects. The aim of this study was to investigate the potential protection of brain tissues afforded...
4.
Pasquini S, Mugnaini C, Ligresti A, Tafi A, Brogi S, Falciani C, et al.
J Med Chem
. 2012 May;
55(11):5391-402.
PMID: 22548457
In our search for new cannabinoid receptor modulators, we describe herein the design and synthesis of three sets of indole-based ligands characterized by an acetamide, oxalylamide, or carboxamide chain, respectively....
5.
Maccioni P, Zaru A, Loi B, Lobina C, Carai M, Gessa G, et al.
Alcohol Clin Exp Res
. 2012 Apr;
36(10):1748-66.
PMID: 22486245
Background: Administration of the GABA(B) receptor agonist, baclofen, and positive allosteric modulator, GS39783, has been repeatedly reported to suppress multiple alcohol-related behaviors, including operant oral alcohol self-administration, in rats. This...
6.
Mugnaini C, Nocerino S, Pedani V, Pasquini S, Tafi A, De Chiaro M, et al.
ChemMedChem
. 2012 Mar;
7(5):920-34.
PMID: 22383251
Three heterocyclic systems were selected as potential bioisosteres of the amide linker for a series of 1,6-disubstituted-4-quinolone-3-carboxamides, which are potent and selective CB2 ligands that exhibit poor water solubility, with...
7.
Lobina C, Carai M, Froestl W, Mugnaini C, Pasquini S, Corelli F, et al.
Front Psychiatry
. 2012 Jan;
2:76.
PMID: 22232609
Recent studies demonstrated that activation of the GABA(B) receptor, either by means of orthosteric agonists or positive allosteric modulators (PAMs), inhibited different nicotine-related behaviors, including intravenous self-administration and conditioned place...
8.
Castelli M, Casu A, Casti P, Lobina C, Carai M, Colombo G, et al.
J Pharmacol Exp Ther
. 2011 Dec;
340(3):529-38.
PMID: 22129594
The potential efficacy of GABA(B) receptor agonists in the treatment of pain, drug addiction, epilepsy, cognitive dysfunctions, and anxiety disorders is supported by extensive preclinical and clinical evidence. However, the...
9.
Piscitelli F, Ligresti A, La Regina G, Gatti V, Brizzi A, Pasquini S, et al.
Eur J Med Chem
. 2011 Oct;
46(11):5641-53.
PMID: 21996466
New 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides were synthesized as cannabinoid (CB) receptor ligands. Compound 11 (CB(1)K(i) = 2.3 nM, CB(1) SI = 163.6) showed CB(1) receptor affinity and selectivity superior to Rimonabant and AM251....
10.
Pasquini S, De Rosa M, Pedani V, Mugnaini C, Guida F, Luongo L, et al.
J Med Chem
. 2011 Jun;
54(15):5444-53.
PMID: 21702498
Experimental evidence suggests that selective CB2 receptor modulators may provide access to antihyperalgesic agents devoid of psychotropic effects. Taking advantage of previous findings on structure-activity/selectivity relationships for a class of...