Senthilkumar Ramamoorthy
Overview
Explore the profile of Senthilkumar Ramamoorthy including associated specialties, affiliations and a list of published articles.
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19
Citations
377
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Recent Articles
1.
Koleci N, Wu Y, Wehner N, Rajak J, Mittapalli V, Mergner J, et al.
Cell Death Dis
. 2025 Mar;
16(1):165.
PMID: 40057493
Juvenile myelomonocytic leukemia (JMML) is caused by constitutively activated RAS signaling and characterized by increased proliferation and predominant myelomonocytic differentiation of hematopoietic cells. Using MxCre;Ptpn11 mice, which model human JMML,...
2.
Subramanian S, Phongbunchoo Y, Cauchy P, Ramamoorthy S
Methods Mol Biol
. 2025 Mar;
2909:179-209.
PMID: 40029523
The dynamic gene expression program of hematopoiesis is controlled by a complex network of regulatory modules consisting of transcription factors, chromatin modifiers, and genomic organizers. Genetic abnormalities or changes in...
3.
Phongbunchoo Y, Braikia F, Pessoa-Rodrigues C, Ramamoorthy S, Ramachandran H, Grosschedl A, et al.
Cell Rep
. 2024 Jul;
43(7):114456.
PMID: 38990722
The rearrangement and expression of the immunoglobulin μ heavy chain (Igh) gene require communication of the intragenic Eμ and 3' regulatory region (RR) enhancers with the variable (V) gene promoter....
4.
Beckmann C, Ramamoorthy S, Trompouki E, Driever W, Schwarz-Furlan S, Strahm B, et al.
Exp Hematol
. 2024 Mar;
133:104207.
PMID: 38522505
Myelodysplastic/myeloproliferative diseases of childhood cause a relevant disease burden, and many of these diseases may have a fatal course. The use of next-generation sequencing (NGS) has led to the identification...
5.
Baumgartner F, Bamopoulos S, Faletti L, Hsiao H, Holz M, Gonzalez-Menendez I, et al.
Sci Signal
. 2024 Feb;
17(824):eadc9662.
PMID: 38377177
The IL-6-gp130-STAT3 signaling axis is a major regulator of inflammation. Activating mutations in the gene encoding gp130 and germline gain-of-function mutations in STAT3 (STAT3) are associated with multi-organ autoimmunity, severe...
6.
Ramamoorthy S, Lebrecht D, Schanze D, Schanze I, Wieland I, Andrieux G, et al.
Br J Haematol
. 2023 Nov;
204(2):595-605.
PMID: 37945316
Juvenile myelomonocytic leukaemia (JMML) is characterized by gene variants that deregulate the RAS signalling pathway. Children with neurofibromatosis type 1 (NF-1) carry a defective NF1 allele in the germline and...
7.
Erlacher M, Andresen F, Sukova M, Stary J, De Moerloose B, Van Der Werff Ten Bosch J, et al.
Haematologica
. 2023 Aug;
109(2):422-430.
PMID: 37584291
Monosomy 7 is the most common cytogenetic abnormality in pediatric myelodysplastic syndrome (MDS) and associated with a high risk of disease progression. However, in young children, spontaneous loss of monosomy...
8.
Andreani V, Ramamoorthy S, Fassler R, Grosschedl R
J Exp Med
. 2022 Nov;
220(1).
PMID: 36350325
Marginal zone (MZ) B cells represent innate-like B cells that mediate a fast immune response. The adhesion of MZ B cells to the marginal sinus of the spleen is governed...
9.
Roy R, Ramamoorthy S, Shapiro B, Kaileh M, Hernandez D, Sarantopoulou D, et al.
Immunity
. 2022 Jun;
55(6):1135.
PMID: 35704994
No abstract available.
10.
Chunduri A, Rajan R, Lima A, Ramamoorthy S, Mamillapalli A
BMC Genomics
. 2022 Apr;
23(1):247.
PMID: 35361117
Background: Chromatin architecture is critical for gene expression during development. Matrix attachment regions (MARs) control and regulate chromatin dynamics. The position of MARs in the genome determines the expression of...