Rudolf Grosschedl
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Explore the profile of Rudolf Grosschedl including associated specialties, affiliations and a list of published articles.
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86
Citations
4719
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Recent Articles
1.
Chen H, Sun Y, Mittler G, Rumpf T, Shvedunova M, Grosschedl R, et al.
Cell Rep
. 2024 Aug;
43(9):114682.
PMID: 39207899
Signaling-dependent changes in protein phosphorylation are critical to enable coordination of transcription and metabolism during macrophage activation. However, the role of acetylation in signal transduction during macrophage activation remains obscure....
2.
Phongbunchoo Y, Braikia F, Pessoa-Rodrigues C, Ramamoorthy S, Ramachandran H, Grosschedl A, et al.
Cell Rep
. 2024 Jul;
43(7):114456.
PMID: 38990722
The rearrangement and expression of the immunoglobulin μ heavy chain (Igh) gene require communication of the intragenic Eμ and 3' regulatory region (RR) enhancers with the variable (V) gene promoter....
3.
Ma F, Cao Y, Du H, Braikia F, Zong L, Ollikainen N, et al.
Nat Cell Biol
. 2024 Jun;
26(6):991-1002.
PMID: 38866970
The contribution of three-dimensional genome organization to physiological ageing is not well known. Here we show that large-scale chromatin reorganization distinguishes young and old bone marrow progenitor (pro-) B cells....
4.
Zolotarev N, Wang Y, Du M, Bayer M, Grosschedl A, Cisse I, et al.
Genes Dev
. 2024 Jan;
38(1-2):4-10.
PMID: 38233109
B lineage priming by pioneer transcription factor EBF1 requires the function of an intrinsically disordered region (IDR). Here, we examine the role of regularly spaced tyrosines in the IDR as...
5.
Schleussner N, Cauchy P, Franke V, Giefing M, Fornes O, Vankadari N, et al.
Nat Commun
. 2023 Nov;
14(1):6947.
PMID: 37935654
Disease-causing mutations in genes encoding transcription factors (TFs) can affect TF interactions with their cognate DNA-binding motifs. Whether and how TF mutations impact upon the binding to TF composite elements...
6.
7.
Zolotarev N, Bayer M, Grosschedl R
Proc Natl Acad Sci U S A
. 2022 Nov;
119(48):e2210595119.
PMID: 36409886
The establishment of de novo chromatin accessibility in lymphoid progenitors requires the "pioneering" function of transcription factor (TF) early B cell factor 1 (EBF1), which binds to naïve chromatin and...
8.
Andreani V, Ramamoorthy S, Fassler R, Grosschedl R
J Exp Med
. 2022 Nov;
220(1).
PMID: 36350325
Marginal zone (MZ) B cells represent innate-like B cells that mediate a fast immune response. The adhesion of MZ B cells to the marginal sinus of the spleen is governed...
9.
Bayer M, Boller S, Ramamoothy S, Zolotarev N, Cauchy P, Iwanami N, et al.
Genes Dev
. 2022 Sep;
36(15-16):901-915.
PMID: 36167471
Transcription factor EBF1 (early B cell factor 1) acts as a key regulator of B cell specification. The transcriptional network in which EBF1 operates has been extensively studied; however, the...
10.
Lenaerts A, Kucinski I, Deboutte W, Derecka M, Cauchy P, Manke T, et al.
J Exp Med
. 2022 Sep;
219(11).
PMID: 36048017
Hematopoietic stem cells (HSCs) and multipotent progenitors (MPPs) generate all cells of the blood system. Despite their multipotency, MPPs display poorly understood lineage bias. Here, we examine whether lineage-specifying transcription...