Scott C Virgil
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Explore the profile of Scott C Virgil including associated specialties, affiliations and a list of published articles.
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57
Citations
749
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Recent Articles
11.
Zhang T, Cusumano A, Hafeman N, Loskot S, Reimann C, Virgil S, et al.
J Org Chem
. 2022 Oct;
87(21):14115-14124.
PMID: 36269312
We utilize ab initio quantum mechanics calculations to evaluate a range of plausible mechanistic pathways for the unexpected formation of a [6-4-4] ring system from an enone-olefin photocycloaddition in the...
12.
Muthusamy A, Kim C, Virgil S, Knox H, Marvin J, Nichols A, et al.
J Am Chem Soc
. 2022 Apr;
144(19):8480-8486.
PMID: 35446570
We report a reagentless, intensity-based S-methadone fluorescent sensor, iS-methadoneSnFR, consisting of a circularly permuted GFP inserted within the sequence of a mutated bacterial periplasmic binding protein (PBP). We evolved a...
13.
Kim A, Ngamnithiporn A, Welin E, Daiger M, Grunanger C, Bartberger M, et al.
ACS Catal
. 2021 May;
10(5):3241-3248.
PMID: 34046244
The development of a general method utilizing a hydroxymethyl directing group for asymmetric hydrogenation of 1,3-disubstituted isoquinolines to provide chiral 1,2,3,4-tetrahydroisoquinolines is reported. The reaction, which utilizes [Ir(cod)Cl] and a...
14.
Yadav P, Khoury S, Mahammed A, Morales M, Virgil S, Gray H, et al.
Org Lett
. 2020 Apr;
22(8):3119-3122.
PMID: 32227962
Separate focus on the oligomerization and oxidative cyclization steps required for the synthesis of 5,10,15-tris(trifluoromethyl)corrole revealed [bis(trifluoroacetoxy)iodo]benzene (PIFA) as a superior alternative oxidant. Under optimized conditions, the pure free-base corrole...
15.
Hafeman N, Loskot S, Reimann C, Pritchett B, Virgil S, Stoltz B
J Am Chem Soc
. 2020 Apr;
142(19):8585-8590.
PMID: 32223255
The first total synthesis of the norcembranoid diterpenoid scabrolide A is disclosed. The route begins with the synthesis of two chiral pool-derived fragments, which undergo a convergent coupling to expediently...
16.
Sun A, Bulterys P, Bartberger M, Jorth P, OBoyle B, Virgil S, et al.
Bioorg Med Chem Lett
. 2019 Aug;
29(18):2686-2689.
PMID: 31383589
gem-Disubstituted N-heterocycles are rarely found in drugs, despite their potential to improve the drug-like properties of small molecule pharmaceuticals. Linezolid, a morpholine heterocycle-containing oxazolidinone antibiotic, exhibits significant side effects associated...
17.
Oppenheim J, Gray M, Di Bilio A, Brennan B, Henling L, Lim P, et al.
Inorg Chem
. 2019 Jul;
58(15):10287-10294.
PMID: 31335126
In aqueous media, hydrophobic metallocorroles form nanoparticles that are potential theranostic anticancer agents. We have analyzed the electronic and Raman spectra of Al(III), Ga(III), and Au(III) corrole nanoparticles (and made...
18.
Craig 2nd R, Smith R, Roizen J, Jones A, Virgil S, Stoltz B
J Org Chem
. 2019 May;
84(12):7722-7746.
PMID: 31066273
Late-stage synthetic efforts to advance the enatio- and diastereoselectively constructed [6,7,5,5]-fused tetracyclic scaffold toward the polycyclic norditerpenoid ineleganolide are disclosed. The described investigations focus on oxidation-state manipulation around the central...
19.
Craig 2nd R, Roizen J, Smith R, Jones A, Virgil S, Stoltz B
Chem Sci
. 2019 Feb;
10(4):1254-1255.
PMID: 30774926
[This corrects the article DOI: 10.1039/C6SC03347D.].
20.
Welin E, Ngamnithiporn A, Klatte M, Lapointe G, Pototschnig G, McDermott M, et al.
Science
. 2018 Dec;
363(6424):270-275.
PMID: 30573544
The bis-tetrahydroisoquinoline (bis-THIQ) natural products have been studied intensively over the past four decades for their exceptionally potent anticancer activity, in addition to strong Gram-positive and Gram-negative antibiotic character. Synthetic...