Russell C Smith
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Explore the profile of Russell C Smith including associated specialties, affiliations and a list of published articles.
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245
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Recent Articles
1.
Chambers C, Grimes S, Smith R, Weil A, Reza M
Chemosphere
. 2024 Dec;
370():143965.
PMID: 39694291
This study highlights the use of loblolly pine derived biochar for the removal of harmful algal bloom toxin, Saxitoxin (STX), from water. Biochar samples were prepared at varying pyrolysis temperatures...
2.
Sterling A, Smith R, Anderson E, Duarte F
J Org Chem
. 2024 Jul;
89(14):9979-9989.
PMID: 38970491
The release of strain energy is a fundamental driving force for organic reactions. However, absolute strain energy alone is an insufficient predictor of reactivity, evidenced by the similar ring strain...
3.
Revie R, Whitaker B, Paul B, Smith R, Anderson E
Org Lett
. 2024 Jan;
26(14):2843-2846.
PMID: 38251922
A route toward heterocycle-functionalized bicyclo[3.1.1]heptanes (BCHeps) and aza-bicyclo[3.1.1]heptanes (aza-BCHeps) has been developed, using mild, photocatalytic Minisci-like conditions to introduce various heterocycles at the bridgehead position from readily available hydroxyphthalimide esters...
4.
Pickford H, Ripenko V, McNamee R, Holovchuk S, Thompson A, Smith R, et al.
Angew Chem Int Ed Engl
. 2022 Oct;
62(3):e202213508.
PMID: 36226350
Sulfonylated aromatics are commonplace motifs in drugs and agrochemicals. However, methods for the direct synthesis of sulfonylated non-classical arene bioisosteres, which could improve the physicochemical properties of drug and agrochemical...
5.
Frank N, Nugent J, Shire B, Pickford H, Rabe P, Sterling A, et al.
Nature
. 2022 Sep;
611(7937):721-726.
PMID: 36108675
Small-ring cage hydrocarbons are popular bioisosteres (molecular replacements) for commonly found para-substituted benzene rings in drug design. The utility of these cage structures derives from their superior pharmacokinetic properties compared...
6.
Pickford H, Nugent J, Owen B, Mousseau J, Smith R, Anderson E
J Am Chem Soc
. 2021 Jun;
143(26):9729-9736.
PMID: 34161076
Bicyclo[1.1.1]pentylamines (BCPAs) are of growing importance to the pharmaceutical industry as sp-rich bioisosteres of anilines and --butyl groups. Here we report a facile synthesis of 1,3-disubstituted BCPAs using a twofold...
7.
Sterling A, Durr A, Smith R, Anderson E, Duarte F
Chem Sci
. 2021 Jun;
11(19):4895-4903.
PMID: 34122945
[1.1.1]Propellane is the ubiquitous precursor to bicyclo[1.1.1]pentanes (BCPs), motifs of high value in pharmaceutical and materials research. The classical Lewis representation of this molecule places an inter-bridgehead C-C bond along...
8.
Leonard K, Madge L, Krawczuk P, Wang A, Kreutter K, Bacani G, et al.
J Med Chem
. 2020 Mar;
63(6):2915-2929.
PMID: 32134643
To identify Janus kinase (JAK) inhibitors that selectively target gastrointestinal tissues with limited systemic exposures, a class of imidazopyrrolopyridines with a range of physical properties was prepared and evaluated. We...
9.
Craig 2nd R, Smith R, Roizen J, Jones A, Virgil S, Stoltz B
J Org Chem
. 2019 May;
84(12):7722-7746.
PMID: 31066273
Late-stage synthetic efforts to advance the enatio- and diastereoselectively constructed [6,7,5,5]-fused tetracyclic scaffold toward the polycyclic norditerpenoid ineleganolide are disclosed. The described investigations focus on oxidation-state manipulation around the central...
10.
Mansfield S, Smith R, Yong J, Garry O, Anderson E
Org Lett
. 2019 Apr;
21(8):2918-2922.
PMID: 30942600
Ynamides are accessed via copper-catalyzed coupling of Grignard or organozinc nucleophiles with chloroynamides, formed in situ from 1,2-dichloroenamides. The reaction exhibits a broad substrate scope, is readily scaled, and overcomes...