Robert A Craig 2nd
Overview
Explore the profile of Robert A Craig 2nd including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
18
Citations
139
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Craig 2nd R, De Vicente J, Estrada A, Feng J, Lexa K, Canet M, et al.
J Med Chem
. 2024 Mar;
67(7):5758-5782.
PMID: 38511649
Eukaryotic translation initiation factor 2B (eIF2B) is a key component of the integrated stress response (ISR), which regulates protein synthesis and stress granule formation in response to cellular insult. Modulation...
2.
Craig 2nd R, Fox B, Hu C, Lexa K, Osipov M, Thottumkara A, et al.
J Med Chem
. 2022 Dec;
65(24):16290-16312.
PMID: 36469401
Dual leucine zipper kinase (DLK) and leucine zipper-bearing kinase (LZK) are regulators of neuronal degeneration and axon growth. Therefore, there is a considerable interest in developing DLK/LZK inhibitors for neurodegenerative...
3.
Craig 2nd R, Garrison C, Nguyen P, Yarov-Yarovoy V, Du Bois J
ACS Chem Neurosci
. 2020 Jan;
11(3):418-426.
PMID: 31951114
Voltage-gated sodium ion channels (Nas) are integral to both neuronal and muscular signaling and are a primary target for a number of proteinaceous and small molecule toxins. Included among these...
4.
Craig 2nd R, Smith R, Roizen J, Jones A, Virgil S, Stoltz B
J Org Chem
. 2019 May;
84(12):7722-7746.
PMID: 31066273
Late-stage synthetic efforts to advance the enatio- and diastereoselectively constructed [6,7,5,5]-fused tetracyclic scaffold toward the polycyclic norditerpenoid ineleganolide are disclosed. The described investigations focus on oxidation-state manipulation around the central...
5.
Craig 2nd R, Roizen J, Smith R, Jones A, Virgil S, Stoltz B
Chem Sci
. 2019 Feb;
10(4):1254-1255.
PMID: 30774926
[This corrects the article DOI: 10.1039/C6SC03347D.].
6.
Craig 2nd R, Smith R, Roizen J, Jones A, Virgil S, Stoltz B
J Org Chem
. 2018 Feb;
83(7):3467-3485.
PMID: 29464957
An enantioselective and diastereoselective approach toward the synthesis of the tetracyclic scaffold of the furanobutenolide-derived polycyclic norditerpenoids is described. Focusing on synthetic efforts toward ineleganolide, the synthetic approach utilizes a...
7.
Craig 2nd R, Smith R, Pritchett B, Estipona B, Stoltz B
Organic Synth
. 2017 Jul;
93:210-227.
PMID: 28729749
No abstract available.
8.
Craig 2nd R, Stoltz B
Chem Rev
. 2017 May;
117(12):7878-7909.
PMID: 28520418
The polycyclic furanobutenolide-derived cembranoid and norcembranoid natural products are a family of congested, stereochemically complex, and extensively oxygenated polycyclic diterpenes and norditerpenes. Although the elegant architectures and biological activity profiles...
9.
Craig 2nd R, Roizen J, Smith R, Jones A, Virgil S, Stoltz B
Chem Sci
. 2017 Feb;
8(1):507-514.
PMID: 28239443
An enantioselective and diastereoselective approach toward the synthesis of the polycyclic norditerpenoid ineleganolide is disclosed. A palladium-catalyzed enantioselective allylic alkylation is employed to stereoselectively construct the requisite chiral tertiary ether...
10.
Estipona B, Pritchett B, Craig 2nd R, Stoltz B
Tetrahedron
. 2016 Aug;
72(26):3707-3712.
PMID: 27546916
A catalytic enantioselective synthesis of (+)-eucomic acid is reported. A palladium-catalyzed asymmetric allylic alkylation is employed to access the chiral tetrasubstituted α-hydroxyacid moiety found in the natural product. The protecting...