Nicholas J Hafeman
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Explore the profile of Nicholas J Hafeman including associated specialties, affiliations and a list of published articles.
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9
Citations
42
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Recent Articles
1.
Chan M, Hafeman N, Fulton T, Stoltz B
Org Lett
. 2024 Jul;
26(30):6320-6323.
PMID: 39046190
Herein, we present a highly efficient method for constructing the intricate 5-5-6 fused ring system commonly found in the polycyclic furanobutenolide-derived cembranoid and norcembranoid natural product family with remarkable diastereoselectivity,...
2.
Kenseth C, Hafeman N, Rezgui S, Chen J, Huang Y, Dalleska N, et al.
Science
. 2023 Nov;
382(6672):787-792.
PMID: 37972156
Secondary organic aerosol (SOA) is ubiquitous in the atmosphere and plays a pivotal role in climate, air quality, and health. The production of low-volatility dimeric compounds through accretion reactions is...
3.
Hafeman N, Loskot S, Reimann C, Pritchett B, Virgil S, Stoltz B
Chem Sci
. 2023 May;
14(18):4745-4758.
PMID: 37181769
The complete account of the total syntheses of scabrolide A and yonarolide is disclosed. This article describes an initial approach involving a bio-inspired macrocyclization/transannular Diels-Alder cascade, which ultimately failed due...
4.
Hafeman N, Chan M, Fulton T, Alexy E, Loskot S, Virgil S, et al.
J Am Chem Soc
. 2022 Oct;
144(44):20232-20236.
PMID: 36287147
The first total synthesis of the furanobutenolide-derived cembranoid diterpenoid havellockate is disclosed. Our convergent strategy employs a Julia-Kocienski olefination to join two enantioenriched fragments to produce a diene that is...
5.
Zhang T, Cusumano A, Hafeman N, Loskot S, Reimann C, Virgil S, et al.
J Org Chem
. 2022 Oct;
87(21):14115-14124.
PMID: 36269312
We utilize ab initio quantum mechanics calculations to evaluate a range of plausible mechanistic pathways for the unexpected formation of a [6-4-4] ring system from an enone-olefin photocycloaddition in the...
6.
Inanaga K, Wollenburg M, Bachman S, Hafeman N, Stoltz B
Chem Sci
. 2020 Nov;
11(28):7390-7395.
PMID: 33133488
The synthesis of a variety of enantioenriched 1,3-diketospiranes from the corresponding racemic allyl β-ketoesters an interrupted asymmetric allylic alkylation is disclosed. Substrates possessing pendant aldehydes undergo decarboxylative enolate formation in...
7.
Kenseth C, Hafeman N, Huang Y, Dalleska N, Stoltz B, Seinfeld J
Environ Sci Technol
. 2020 Aug;
54(20):12829-12839.
PMID: 32813970
Liquid chromatography/negative electrospray ionization mass spectrometry [LC/(-)ESI-MS] is routinely employed to characterize the identity and abundance of molecular products in secondary organic aerosol (SOA) derived from monoterpene oxidation. Due to...
8.
Hafeman N, Loskot S, Reimann C, Pritchett B, Virgil S, Stoltz B
J Am Chem Soc
. 2020 Apr;
142(19):8585-8590.
PMID: 32223255
The first total synthesis of the norcembranoid diterpenoid scabrolide A is disclosed. The route begins with the synthesis of two chiral pool-derived fragments, which undergo a convergent coupling to expediently...
9.
Antanasijevic A, Hafeman N, Tundup S, Kingsley C, Mishra R, Rong L, et al.
ACS Infect Dis
. 2016 Oct;
2(9):608-615.
PMID: 27759373
The viral envelope protein hemagglutinin (HA) plays a critical role in influenza entry and thus is an attractive target for novel therapeutics. The small molecule tert-butylhydroquinone (TBHQ) has previously been...