Scott C Virgil
Overview
Explore the profile of Scott C Virgil including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
57
Citations
749
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Bosse A, Hunt L, Suarez C, Casselman T, Goldstein E, Wright A, et al.
Science
. 2024 Nov;
386(6722):641-646.
PMID: 39509484
(-)-Cylindrocyclophane A is a 22-membered C-symmetric [7.7]paracyclophane that bears bis-resorcinol functionality and six stereocenters. We report a synthetic strategy for (-)-cylindrocyclophane A that uses 10 C-H functionalization reactions, resulting in...
2.
Rezgui S, Farhi J, Yu H, Sercel Z, Virgil S, Stoltz B
Chem Sci
. 2024 Aug;
15(31):12284-12290.
PMID: 39118607
Pyrroloiminoquinone alkaloids are a large class of natural products that display a wide range of biological activities. Synthetic approaches to these natural products typically rely on a common late-stage C10-oxygenated...
3.
Stanko A, Ramirez M, de Almenara A, Virgil S, Stoltz B
Org Lett
. 2024 Aug;
26(32):6793-6797.
PMID: 39087908
Herein we report a strategy for the enantioselective synthesis of spirocycles containing all-carbon quaternary centers via nickel-catalyzed intramolecular addition of lactone enolates to aryl nitriles. The established lactone α-spirocyclization efficiently...
4.
Samkian A, Virgil S, Stoltz B
J Am Chem Soc
. 2024 Jul;
146(28):18886-18891.
PMID: 38958271
We report the first total synthesis of hypersampsone M, an archetypal member of the homoadamantane polycyclic polyprenylated acylphloroglucinols (PPAPs). Commencing from cyclohexenone, a key cyclopentene annulation followed by ring-expansion results...
5.
Hanley D, Li Z, Gao S, Virgil S, Arnold F, Alfonzo E
J Am Chem Soc
. 2024 Jul;
146(28):19160-19167.
PMID: 38958264
Boronic acids and esters are highly regarded for their safety, unique reactivity, and versatility in synthesizing a wide range of small molecules, bioconjugates, and materials. They are not exploited in...
6.
Yu H, Sercel Z, Rezgui S, Farhi J, Virgil S, Stoltz B
J Am Chem Soc
. 2023 Nov;
145(47):25533-25537.
PMID: 37967164
Aleutianamine is a recently isolated pyrroloiminoquinone natural product that displays potent and selective biological activity toward human pancreatic cancer cells with an IC of 25 nM against PANC-1, making it...
7.
Hafeman N, Loskot S, Reimann C, Pritchett B, Virgil S, Stoltz B
Chem Sci
. 2023 May;
14(18):4745-4758.
PMID: 37181769
The complete account of the total syntheses of scabrolide A and yonarolide is disclosed. This article describes an initial approach involving a bio-inspired macrocyclization/transannular Diels-Alder cascade, which ultimately failed due...
8.
Gross B, Han S, Virgil S, Stoltz B
J Am Chem Soc
. 2023 Mar;
145(14):7763-7767.
PMID: 36989438
We report the total synthesis of the furanobutenolide-derived diterpenoid (+)-ineleganolide. The synthetic approach relies on a convergent strategy based on the coupling of two enantioenriched fragments, which are derived from...
9.
Rand A, Gonzalez K, Reimann C, Virgil S, Stoltz B
J Am Chem Soc
. 2023 Mar;
145(13):7278-7287.
PMID: 36952571
Strempeliopidine is a member of the monoterpenoid bisindole alkaloid family, a class of natural products that have been shown to elicit an array of biological responses including modulating protein-protein interactions...
10.
Hafeman N, Chan M, Fulton T, Alexy E, Loskot S, Virgil S, et al.
J Am Chem Soc
. 2022 Oct;
144(44):20232-20236.
PMID: 36287147
The first total synthesis of the furanobutenolide-derived cembranoid diterpenoid havellockate is disclosed. Our convergent strategy employs a Julia-Kocienski olefination to join two enantioenriched fragments to produce a diene that is...