Sarah C Sim
Overview
Explore the profile of Sarah C Sim including associated specialties, affiliations and a list of published articles.
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25
Citations
1068
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Recent Articles
1.
Hendriks D, Vorrink S, Smutny T, Sim S, Nordling A, Ullah S, et al.
Clin Pharmacol Ther
. 2020 Apr;
108(4):844-855.
PMID: 32320483
Cytochrome P450 (CYP) 3A4 induction is an important cause of drug-drug interactions, making early identification of drug candidates with CYP3A4 induction liability in drug development a prerequisite. Here, we present...
2.
Sim S, Ingelman-Sundberg M
Methods Mol Biol
. 2016 Oct;
320:183-191.
PMID: 27699669
Interindividual variability in xenobiotic metabolism and drug response is extensive. Genetic factors are predicted to account for 15-30% of this variability in general, but for certain drugs the genetic factor...
3.
Chaudhry A, Prasad B, Shirasaka Y, Fohner A, Finkelstein D, Fan Y, et al.
Drug Metab Dispos
. 2015 May;
43(8):1226-35.
PMID: 26021325
CYP2C19 rs12769205 alters an intron 2 branch point adenine leading to an alternative mRNA in human liver with complete inclusion of intron 2 (exon 2B). rs12769205 changes the mRNA reading...
4.
Sim S, Ingelman-Sundberg M
Methods Mol Biol
. 2013 Mar;
987:251-9.
PMID: 23475683
Interindividual variability in xenobiotic metabolism and drug response is extensive and genetic factors play an important role in this variation. A majority of clinically used drugs are substrates for the...
5.
6.
Eliasson E, Sim S, Rane A, Ingelman-Sundberg M
Pharmacogenomics
. 2012 Dec;
13(16):1887-91.
PMID: 23215881
Research in pharmacogenomics has been intensive at Karolinska Institutet (KI) for approximately 25 years. Initial initiatives were focused on the identification and characterization of novel CYP2D6 alleles causing ultrarapid or...
7.
Peyrot W, Middeldorp C, Jansen R, Smit J, de Geus E, Hottenga J, et al.
J Affect Disord
. 2012 Oct;
146(1):91-9.
PMID: 23021380
Background: There is ongoing interest in the possible interaction of the serotonin-transporter-linked polymorphic region (5-HTTLPR) with environmental factors in determining Major Depressive Disorder (MDD). The current study contributes to this...
8.
Sim S, Daly A, Gaedigk A
Pharmacogenet Genomics
. 2012 Aug;
22(9):692-4.
PMID: 22868903
No abstract available.
9.
Sim S, Altman R, Ingelman-Sundberg M
Hum Mutat
. 2011 Feb;
32(5):526-31.
PMID: 21309040
In the area of pharmacogenetics and personalized health care it is obvious that databases, providing important information of the occurrence and consequences of variant genes encoding drug metabolizing enzymes, drug...
10.
Sim S, Ingelman-Sundberg M
Trends Pharmacol Sci
. 2010 Dec;
32(2):72-81.
PMID: 21185092
The rapid development of techniques in the area of genome analysis has facilitated identification of new pharmacogenomic biomarkers that can provide predictive tools for improved drug response and fewer adverse...