Sarah C Sim
Overview
Explore the profile of Sarah C Sim including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
25
Citations
1068
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
11.
Ingelman-Sundberg M, Sim S
Hum Genomics
. 2010 Sep;
4(6):402-5.
PMID: 20846929
The cytochrome P450 enzymes active in drug metabolism are highly polymorphic. Most allelic variants have been described for enzymes encoded by the cytochrome P450 family 2 (CYP2) gene family, which...
12.
Pedersen R, Brasch-Andersen C, Sim S, Bergmann T, Halling J, Petersen M, et al.
Eur J Clin Pharmacol
. 2010 Jul;
66(12):1199-205.
PMID: 20665013
Purpose: To determine the distribution of clinically important CYP2C genotypes and allele frequencies in healthy Nordic populations with special focus on linkage disequilibrium. Methods: A total of 896 healthy subjects...
13.
Sim S, Ingelman-Sundberg M
Hum Genomics
. 2010 Jun;
4(4):278-81.
PMID: 20511141
Pharmacogenetics affects both pharmacokinetics and pharmacodynamics, thereby influencing an individual's response to drugs, both in terms of response and adverse reactions. Within the area of pharmacogenetics, findings of genetic variation...
14.
Ingelman-Sundberg M, Sim S
Biochem Biophys Res Commun
. 2010 May;
396(1):90-4.
PMID: 20494117
Important interindividual differences in drug pharmacokinetics cause absence of drug response or adverse drug reactions in significant fractions of the populations. The identification of the major enzymes participating, and the...
15.
Sim S, Nordin L, Andersson T, Virding S, Olsson M, Pedersen N, et al.
Am J Med Genet B Neuropsychiatr Genet
. 2010 May;
153B(6):1160-6.
PMID: 20468063
Cytochrome P450 2C19 (CYP2C19) is a polymorphic enzyme active in the metabolism of for example diazepam and the antidepressants sertraline, citalopram, and escitalopram, whereby allelic variants cause increased (CYP2C19*17) or...
16.
Rodriguez-Antona C, Gomez A, Karlgren M, Sim S, Ingelman-Sundberg M
Hum Genet
. 2009 Oct;
127(1):1-17.
PMID: 19823875
The cytochromes P450 (CYPs) are very efficient catalysts of foreign compound metabolism and are responsible for the major part of metabolism of clinically important drugs. The enzymes are important in...
17.
Sim S, Miller W, Zhong X, Arlt W, Ogata T, Ding X, et al.
Pharmacogenet Genomics
. 2009 Jun;
19(7):565-6.
PMID: 19535965
No abstract available.
18.
Ohlsson Rosenborg S, Mwinyi J, Andersson M, Baldwin R, Pedersen R, Sim S, et al.
Eur J Clin Pharmacol
. 2008 Jul;
64(12):1175-9.
PMID: 18654768
Purpose: Ultrarapid drug metabolism of antidepressants has been associated with therapeutic failures. The CYP2C19*17 allele has been associated with higher levels of CYP2C19 gene transcription and increased rates of omeprazole...
19.
Lofgren S, Baldwin R, Hiratsuka M, Lindqvist A, Carlberg A, Sim S, et al.
Drug Metab Dispos
. 2008 Feb;
36(5):955-62.
PMID: 18276835
CYP2C19 is an important enzyme for human drug metabolism, and it also participates in the metabolism of endogenous substrates, whereas the CYP2C18 enzyme is not expressed in human liver despite...
20.
Ingelman-Sundberg M, Sim S, Gomez A, Rodriguez-Antona C
Pharmacol Ther
. 2007 Nov;
116(3):496-526.
PMID: 18001838
The polymorphic nature of the cytochrome P450 (CYP) genes affects individual drug response and adverse reactions to a great extent. This variation includes copy number variants (CNV), missense mutations, insertions...