Sara Marsango
Overview
Explore the profile of Sara Marsango including associated specialties, affiliations and a list of published articles.
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Articles
26
Citations
251
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Recent Articles
1.
Ieremias L, Kaspersen M, Manandhar A, Schultz-Knudsen K, Vrettou C, Pokhrel R, et al.
J Med Chem
. 2024 Feb;
67(5):3542-3570.
PMID: 38381650
GPR84 is a putative medium-chain fatty acid receptor that is implicated in regulation of inflammation and fibrogenesis. Studies have indicated that GPR84 agonists may have therapeutic potential in diseases such...
2.
Kalita M, Park J, Kuo R, Hayee S, Marsango S, Straniero V, et al.
JACS Au
. 2023 Dec;
3(12):3297-3310.
PMID: 38155640
Chronic innate immune activation is a key hallmark of many neurological diseases and is known to result in the upregulation of GPR84 in myeloid cells (macrophages, microglia, and monocytes). As...
3.
Barki N, Jenkins L, Marsango S, Dedeo D, Bolognini D, Dwomoh L, et al.
Elife
. 2023 Dec;
12.
PMID: 38085667
Free fatty acid receptor 2 (FFAR2) is activated by short-chain fatty acids and expressed widely, including in white adipocytes and various immune and enteroendocrine cells. Using both wild-type human FFAR2...
4.
Zhang X, Wang Y, Supekar S, Cao X, Zhou J, Dang J, et al.
Nat Commun
. 2023 Sep;
14(1):5706.
PMID: 37709767
GPR84 is a unique orphan G protein-coupled receptor (GPCR) that can be activated by endogenous medium-chain fatty acids (MCFAs). The signaling of GPR84 is largely pro-inflammatory, which can augment inflammatory...
5.
Marsango S, Milligan G
Br J Pharmacol
. 2023 Apr;
181(10):1500-1508.
PMID: 37085331
GPR84 is an understudied rhodopsin-like class A G protein-coupled receptor, which is arousing particular interest from a therapeutic perspective. Not least this reflects that gpr84 expression is significantly up-regulated following...
6.
Zhang X, Wang Y, Supekar S, Cao X, Zhou J, Dang J, et al.
Res Sq
. 2023 Feb;
PMID: 36824923
GPR84 is a unique orphan G protein-coupled receptor (GPCR) that can be activated by endogenous medium-chain fatty acids (MCFAs). The signaling of GPR84 is largely pro-inflammatory, which can augment inflammatory...
7.
Mahindra A, Jenkins L, Marsango S, Huggett M, Huggett M, Robinson L, et al.
J Med Chem
. 2022 Aug;
65(16):11270-11290.
PMID: 35948061
G-protein-coupled receptor 84 (GPR84) is a proinflammatory orphan G-protein-coupled receptor implicated in several inflammatory and fibrotic diseases. Several agonist and antagonist ligands have been developed that target GPR84; however, a...
8.
Marsango S, Jenkins L, Pediani J, Bradley S, Ward R, Hesse S, et al.
Proc Natl Acad Sci U S A
. 2022 Jun;
119(24):e2201103119.
PMID: 35671422
The quaternary organization of rhodopsin-like G protein-coupled receptors in native tissues is unknown. To address this we generated mice in which the M muscarinic acetylcholine receptor was replaced with a...
9.
Marsango S, Ward R, Jenkins L, Butcher A, Al Mahmud Z, Dwomoh L, et al.
J Biol Chem
. 2022 Apr;
298(5):101932.
PMID: 35427647
GPR84 is an immune cell-expressed, proinflammatory receptor currently being assessed as a therapeutic target in conditions including fibrosis and inflammatory bowel disease. Although it was previously shown that the orthosteric...
10.
Scarpa M, Molloy C, Jenkins L, Strellis B, Budgett R, Hesse S, et al.
Proc Natl Acad Sci U S A
. 2021 Dec;
118(50).
PMID: 34893539
There are currently no treatments that can slow the progression of neurodegenerative diseases, such as Alzheimer's disease (AD). There is, however, a growing body of evidence that activation of the...