Richard J Ward
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Explore the profile of Richard J Ward including associated specialties, affiliations and a list of published articles.
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84
Citations
1039
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Recent Articles
1.
Chetwynd S, Ward R, Milligan G, Welch H
J Biol Chem
. 2024 Oct;
300(12):107940.
PMID: 39476960
Norbin (Neurochondrin, NCDN) is a G protein-coupled receptor (GPCR) adaptor protein known for its importance in neuronal function. Norbin works by binding to numerous GPCRs, controlling their steady-state trafficking and...
2.
Alves G, de Andrades D, Salgado J, Mariano C, Berto G, Segato F, et al.
Int J Biol Macromol
. 2024 Sep;
280(Pt 2):135816.
PMID: 39306183
Acetylxylan esterases (AXEs) are essential enzymes that break down the acetyl groups in acetylated xylan found in plant cell walls polysaccharides. They work synergistically with backbone-depolymerizing xylanolytic enzymes to accelerate...
3.
de Andrades D, Alnoch R, Alves G, Salgado J, Almeida P, Berto G, et al.
Bioresour Bioprocess
. 2024 Jul;
11(1):77.
PMID: 39073555
The β-glucosidase gene from Aspergillus nidulans FGSC A4 was cloned and overexpressed in the A. nidulans A773. The resulting purified β-glucosidase, named AnGH3, is a monomeric enzyme with a molecular...
4.
Zhou X, Septien-Gonzalez H, Husaini S, Ward R, Milligan G, Gradinaru C
J Phys Chem B
. 2024 Apr;
128(18):4354-4366.
PMID: 38683784
G protein-coupled receptors (GPCRs) are a major gateway to cellular signaling, which respond to ligands binding at extracellular sites through allosteric conformational changes that modulate their interactions with G proteins...
5.
Garbelotti C, Bulmer G, Ward R, van Munster J
Food Chem
. 2022 Nov;
405(Pt B):134939.
PMID: 36403470
Ferulic acid has antioxidant properties of interest to the food industry and can be released from natural plant fibres using feruloyl esterases. Esterases active at high temperatures are highly desirable...
6.
Marsango S, Jenkins L, Pediani J, Bradley S, Ward R, Hesse S, et al.
Proc Natl Acad Sci U S A
. 2022 Jun;
119(24):e2201103119.
PMID: 35671422
The quaternary organization of rhodopsin-like G protein-coupled receptors in native tissues is unknown. To address this we generated mice in which the M muscarinic acetylcholine receptor was replaced with a...
7.
Marsango S, Ward R, Jenkins L, Butcher A, Al Mahmud Z, Dwomoh L, et al.
J Biol Chem
. 2022 Apr;
298(5):101932.
PMID: 35427647
GPR84 is an immune cell-expressed, proinflammatory receptor currently being assessed as a therapeutic target in conditions including fibrosis and inflammatory bowel disease. Although it was previously shown that the orthosteric...
8.
Alhallak I, Wolter K, Castro Munoz A, Simmen F, Ward R, Petty S, et al.
J Mol Endocrinol
. 2021 Aug;
67(4):173-188.
PMID: 34382943
Epidemiological studies inversely associate BMI with breast cancer risk in premenopausal women, but the pathophysiological linkage remains ill-defined. Despite the documented relevance of the 'local' environment to breast cancer progression...
9.
Pinheiro M, Reis R, Dupree P, Ward R
Comput Struct Biotechnol J
. 2021 Mar;
19:1108-1118.
PMID: 33680354
Effective use of plant biomass as an abundant and renewable feedstock for biofuel production and biorefinery requires efficient enzymatic mobilization of cell wall polymers. Knowledge of plant cell wall composition...
10.
Ward R, Pediani J, Marsango S, Jolly R, Stoneman M, Biener G, et al.
J Biol Chem
. 2020 Dec;
296:100139.
PMID: 33268380
CXCR4, a member of the family of chemokine-activated G protein-coupled receptors, is widely expressed in immune response cells. It is involved in both cancer development and progression as well as...