Santosh S Kulkarni
Overview
Explore the profile of Santosh S Kulkarni including associated specialties, affiliations and a list of published articles.
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Articles
19
Citations
232
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Recent Articles
1.
Orliac A, Routier J, Charvillon F, Sauer W, Bombrun A, Kulkarni S, et al.
Chemistry
. 2014 Feb;
20(13):3813-24.
PMID: 24532344
The enantioselective syntheses of 3-amino-5-fluoropiperidines and 3-amino-5,5-difluoropiperidines were developed using the ring enlargement of prolinols to access libraries of 3-amino- and 3-amidofluoropiperidines. The study of the physicochemical properties revealed that...
2.
Heinrich T, Seenisamy J, Emmanuvel L, Kulkarni S, Bomke J, Rohdich F, et al.
J Med Chem
. 2013 Jan;
56(3):1160-70.
PMID: 23294348
Focal adhesion kinase (FAK) is considered as an attractive target for oncology, and small-molecule inhibitors are reported to be in clinical testing. In a surface plasmon resonance (SPR)-mediated fragment screening...
3.
Ross N, Kulkarni S, McLaughlin J, Aldrich J
Tetrahedron Lett
. 2012 Aug;
51(38):5020-5023.
PMID: 22865937
The tryptophan isomers of the cyclic tetrapeptide CJ-15,208, reported to be a kappa opioid receptor (KOR) antagonist [Saito, T.; Hirai, H.; Kim, Y. J.; Kojima, Y.; Matsunaga, Y.; Nishida, H.;...
4.
Aldrich J, Kulkarni S, Senadheera S, Ross N, Reilley K, Eans S, et al.
ChemMedChem
. 2011 Jul;
6(9):1739-45.
PMID: 21761566
An alanine scan was performed on the novel κ opioid receptor (KOR) peptide ligand CJ-15,208 to determine which residues contribute to the potent in vivo agonist activity observed for the...
5.
Kulkarni S, Zou M, Cao J, Deschamps J, Rodriguez A, Conn P, et al.
J Med Chem
. 2009 May;
52(11):3563-75.
PMID: 19445453
The metabotropic glutamate receptor subtype 5 (mGluR5) has been implicated in anxiety, depression, pain, mental retardation, and addiction. The potent and selective noncompetitive mGluR5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP, 1) has been...
6.
Fang W, Kulkarni S, Murray T, Aldrich J
Adv Exp Med Biol
. 2009 Apr;
611:279-80.
PMID: 19400192
No abstract available.
7.
Kulkarni S, Ross N, McLaughlin J, Aldrich J
Adv Exp Med Biol
. 2009 Apr;
611:269-70.
PMID: 19400188
No abstract available.
8.
Kulkarni S, Newman A
Bioorg Med Chem Lett
. 2007 Apr;
17(11):2987-91.
PMID: 17446071
Investigation of a series of heterobicyclic compounds with essential pharmacophoric features of the metabotropic glutamate receptor 5 (mGluR5) antagonists MPEP and MTEP provided novel structural templates with sub-micromolar affinities at...
9.
Kulkarni S, Newman A
Bioorg Med Chem Lett
. 2007 Mar;
17(7):2074-9.
PMID: 17336520
A series of heterobiaryl amides was designed and synthesized as novel mGluR5 antagonists. The synthesis using palladium catalyzed Suzuki-Miyaura cross-coupling reactions provided an array of compounds with a range of...
10.
Vaughan R, Sakrikar D, Parnas M, Adkins S, Foster J, Duval R, et al.
J Biol Chem
. 2007 Jan;
282(12):8915-25.
PMID: 17255098
The site of cocaine binding on the dopamine transporter (DAT) was investigated using the photoactivatable irreversible cocaine analog [125I]3beta-(p-chlorophenyl)tropane-2beta-carboxylic acid, 4'-azido-3'-iodophenylethyl ester ([125I]RTI 82). The incorporation site of this compound...