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Synthesis of Cyclic Tetrapeptide CJ 15,208: a Novel Kappa Opioid Receptor Antagonist

Overview
Journal Adv Exp Med Biol
Specialties Biology
General Medicine
Date 2009 Apr 30
PMID 19400188
Citations 7
Authors
Santosh S Kulkarni
Nicolette C Ross
Jay P McLaughlin
Jane V Aldrich
Affiliations
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Citing Articles

Controversy of Peptide Cyclization from Tripeptide.

Lin C, Chakraborty S, Wong C, Tai D Molecules. 2021; 26(2).

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Phenylalanine Stereoisomers of CJ-15,208 and [d-Trp]CJ-15,208 Exhibit Distinctly Different Opioid Activity Profiles.

Brice-Tutt A, Senadheera S, Ganno M, Eans S, Khaliq T, Murray T Molecules. 2020; 25(17).

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Alanine analogues of [D-Trp]CJ-15,208: novel opioid activity profiles and prevention of drug- and stress-induced reinstatement of cocaine-seeking behaviour.

Aldrich J, Senadheera S, Ross N, Reilley K, Ganno M, Eans S Br J Pharmacol. 2014; 171(13):3212-22.

PMID: 24588614 PMC: 4080975. DOI: 10.1111/bph.12664.

The macrocyclic tetrapeptide [D-Trp]CJ-15,208 produces short-acting κ opioid receptor antagonism in the CNS after oral administration.

Eans S, Ganno M, Reilley K, Patkar K, Senadheera S, Aldrich J Br J Pharmacol. 2013; 169(2):426-36.

PMID: 23425081 PMC: 3651667. DOI: 10.1111/bph.12132.

The macrocyclic peptide natural product CJ-15,208 is orally active and prevents reinstatement of extinguished cocaine-seeking behavior.

Aldrich J, Senadheera S, Ross N, Ganno M, Eans S, McLaughlin J J Nat Prod. 2013; 76(3):433-8.

PMID: 23327691 PMC: 3879116. DOI: 10.1021/np300697k.