Samuel C Durley
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Explore the profile of Samuel C Durley including associated specialties, affiliations and a list of published articles.
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Articles
7
Citations
124
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Recent Articles
1.
Pai C, Durley S, Cheng W, Chiang N, Peters J, Kasparek T, et al.
Nucleic Acids Res
. 2023 Mar;
51(7):3205-3222.
PMID: 36951111
Chromosomal instability (CIN) drives cell-to-cell heterogeneity, and the development of genetic diseases, including cancer. Impaired homologous recombination (HR) has been implicated as a major driver of CIN, however, the underlying...
2.
van Bijsterveldt L, Durley S, Maughan T, Humphrey T
Clin Cancer Res
. 2020 Dec;
27(4):937-962.
PMID: 33257428
Preclinical models of cancer have demonstrated enhanced efficacy of cell-cycle checkpoint kinase inhibitors when used in combination with genotoxic agents. This combination therapy is predicted to be exquisitely toxic to...
3.
Dave A, Pai C, Durley S, Hulme L, Sarkar S, Wee B, et al.
Nucleic Acids Res
. 2019 Dec;
48(3):1271-1284.
PMID: 31828313
The healing of broken chromosomes by de novo telomere addition, while a normal developmental process in some organisms, has the potential to cause extensive loss of heterozygosity, genetic disease, or...
4.
Pai C, Hsu K, Durley S, Keszthelyi A, Kearsey S, Rallis C, et al.
J Cell Sci
. 2019 Jan;
132(6).
PMID: 30674555
Replication stress is a common feature of cancer cells, and thus a potentially important therapeutic target. Here, we show that cyclin-dependent kinase (CDK)-induced replication stress, resulting from Wee1 inactivation, is...
5.
Maruyama H, Harwood J, Moore K, Paszkiewicz K, Durley S, Fukushima H, et al.
EMBO Rep
. 2013 Jul;
14(8):711-7.
PMID: 23835508
We have applied chromatin sequencing technology to the euryarchaeon Thermococcus kodakarensis, which is known to possess histone-like proteins. We detect positioned chromatin particles of variable sizes associated with lengths of...
6.
Chambers A, Ormerod G, Durley S, Sing T, Brown G, Kent N, et al.
Genes Dev
. 2012 Dec;
26(23):2590-603.
PMID: 23207916
The INO80 chromatin remodeling complex functions in transcriptional regulation, DNA repair, and replication. Here we uncover a novel role for INO80 in regulating chromosome segregation. First, we show that the...
7.
Chambers A, Brownlee P, Durley S, Beacham T, Kent N, Downs J
PLoS One
. 2012 Feb;
7(2):e32016.
PMID: 22359657
The RSC chromatin remodeling complex has been implicated in contributing to DNA double-strand break (DSB) repair in a number of studies. Both survival and levels of H2A phosphorylation in response...