Anna L Chambers
Overview
Explore the profile of Anna L Chambers including associated specialties, affiliations and a list of published articles.
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14
Citations
637
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Recent Articles
1.
Ballisat L, De Sio C, Beck L, Chambers A, Dillingham M, Guatelli S, et al.
Phys Med
. 2024 Dec;
129():104871.
PMID: 39667143
Purpose: Understanding cell cycle variations in radiosensitivity is important for α-particle therapies. Differences are due to both repair response mechanisms and the quantity of initial radiation-induced DNA strand breaks. Genome...
2.
Kollarovic G, Topping C, Shaw E, Chambers A
Nucleic Acids Res
. 2019 Dec;
48(4):1872-1885.
PMID: 31802118
Efficient double-strand break repair in eukaryotes requires manipulation of chromatin structure. ATP-dependent chromatin remodelling enzymes facilitate different DNA repair pathways, during different stages of the cell cycle and in varied...
3.
Gupta K, Watson A, Baptista T, Scheer E, Chambers A, Koehler C, et al.
Elife
. 2017 Nov;
6.
PMID: 29111974
General transcription factor TFIID is a key component of RNA polymerase II transcription initiation. Human TFIID is a megadalton-sized complex comprising TATA-binding protein (TBP) and 13 TBP-associated factors (TAFs). TBP...
4.
Schalbetter S, Mansoubi S, Chambers A, Downs J, Baxter J
Proc Natl Acad Sci U S A
. 2015 Aug;
112(33):E4565-70.
PMID: 26240319
Faithful genome duplication and inheritance require the complete resolution of all intertwines within the parental DNA duplex. This is achieved by topoisomerase action ahead of the replication fork or by...
5.
Kakarougkas A, Ismail A, Chambers A, Riballo E, Herbert A, Kunzel J, et al.
Mol Cell
. 2014 Jul;
55(5):723-32.
PMID: 25066234
Actively transcribed regions of the genome are vulnerable to genomic instability. Recently, it was discovered that transcription is repressed in response to neighboring DNA double-strand breaks (DSBs). It is not...
6.
Brownlee P, Chambers A, Cloney R, Bianchi A, Downs J
Cell Rep
. 2014 Mar;
6(6):973-981.
PMID: 24613357
BAF180, a subunit of the PBAF chromatin remodeling complex, is frequently mutated in cancer. Although PBAF regulates transcription, it remains unclear whether this is what drives tumorigenesis in cells lacking...
7.
Chambers A, Pearl L, Oliver A, Downs J
Nucleic Acids Res
. 2013 Aug;
41(19):9168-82.
PMID: 23907388
Bromo-adjacent homology (BAH) domains are commonly found in chromatin-associated proteins and fall into two classes; Remodels the Structure of Chromatin (RSC)-like or Sir3-like. Although Sir3-like BAH domains bind nucleosomes, the...
8.
Chambers A, Ormerod G, Durley S, Sing T, Brown G, Kent N, et al.
Genes Dev
. 2012 Dec;
26(23):2590-603.
PMID: 23207916
The INO80 chromatin remodeling complex functions in transcriptional regulation, DNA repair, and replication. Here we uncover a novel role for INO80 in regulating chromosome segregation. First, we show that the...
9.
Chambers A, Downs J
Prog Mol Biol Transl Sci
. 2012 Jul;
110:229-61.
PMID: 22749148
In eukaryotes, DNA is packaged into chromatin and is therefore relatively inaccessible to DNA repair enzymes. In order to perform efficient DNA repair, ATP-dependent chromatin-remodeling enzymes are required to alter...
10.
Niimi A, Chambers A, Downs J, Lehmann A
Nucleic Acids Res
. 2012 May;
40(15):7393-403.
PMID: 22638582
In eukaryotic cells, replication past damaged sites in DNA is regulated by the ubiquitination of proliferating cell nuclear antigen (PCNA). Little is known about how this process is affected by...