Stephen E Kearsey
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Explore the profile of Stephen E Kearsey including associated specialties, affiliations and a list of published articles.
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34
Citations
1461
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Recent Articles
1.
Pai C, Durley S, Cheng W, Chiang N, Peters J, Kasparek T, et al.
Nucleic Acids Res
. 2023 Mar;
51(7):3205-3222.
PMID: 36951111
Chromosomal instability (CIN) drives cell-to-cell heterogeneity, and the development of genetic diseases, including cancer. Impaired homologous recombination (HR) has been implicated as a major driver of CIN, however, the underlying...
2.
Pai C, Heitzer E, Bertrand S, Toumazou S, Humphrey T, Kearsey S
PLoS One
. 2023 Jan;
18(1):e0271016.
PMID: 36626373
We constructed a panel of S. pombe strains expressing DNA polymerase ε variants associated with cancer, specifically POLES297F, POLEV411L, POLEL424V, POLES459F, and used these to compare mutation rates determined by...
3.
Soriano I, Vazquez E, de Leon N, Bertrand S, Heitzer E, Toumazou S, et al.
PLoS Genet
. 2021 Jul;
17(7):e1009526.
PMID: 34228709
Somatic and germline mutations in the proofreading domain of the replicative DNA polymerase ε (POLE-exonuclease domain mutations, POLE-EDMs) are frequently found in colorectal and endometrial cancers and, occasionally, in other...
4.
Pai C, Hsu K, Durley S, Keszthelyi A, Kearsey S, Rallis C, et al.
J Cell Sci
. 2019 Jan;
132(6).
PMID: 30674555
Replication stress is a common feature of cancer cells, and thus a potentially important therapeutic target. Here, we show that cyclin-dependent kinase (CDK)-induced replication stress, resulting from Wee1 inactivation, is...
5.
Pai C, Kishkevich A, Deegan R, Keszthelyi A, Folkes L, Kearsey S, et al.
Cell Rep
. 2017 Sep;
20(11):2693-2705.
PMID: 28903048
Chromatin modification through histone H3 lysine 36 methylation by the SETD2 tumor suppressor plays a key role in maintaining genome stability. Here, we describe a role for Set2-dependent H3K36 methylation...
6.
Pai C, Kearsey S
Genes (Basel)
. 2017 Feb;
8(2).
PMID: 28146119
A crucial factor in maintaining genome stability is establishing deoxynucleoside triphosphate (dNTP) levels within a range that is optimal for chromosomal replication. Since DNA replication is relevant to a wide...
7.
Rayner E, Van Gool I, Palles C, Kearsey S, Bosse T, Tomlinson I, et al.
Nat Rev Cancer
. 2016 Jan;
16(2):71-81.
PMID: 26822575
Although it has long been recognized that the exonucleolytic proofreading activity intrinsic to the replicative DNA polymerases Pol δ and Pol ε is essential for faithful replication of DNA, evidence...
8.
Guarino E, Cojoc G, Garcia-Ulloa A, Tolic I, Kearsey S
PLoS One
. 2014 Nov;
9(11):e113325.
PMID: 25409521
Analysis of accumulation of repair and checkpoint proteins at repair sites in yeast nuclei has conventionally used chemical agents, ionizing radiation or induction of endonucleases to inflict localized damage. In...
9.
Guarino E, Salguero I, Kearsey S
Semin Cell Dev Biol
. 2014 Apr;
30:97-103.
PMID: 24704278
Synthesis of deoxynucleoside triphosphates (dNTPs) is essential for both DNA replication and repair and a key step in this process is catalyzed by ribonucleotide reductases (RNRs), which reduce ribonucleotides (rNDPs)...
10.
Hua H, Namdar M, Ganier O, Gregan J, Mechali M, Kearsey S
Mol Biol Cell
. 2013 Jan;
24(5):578-87.
PMID: 23303250
Meiosis involves two successive rounds of chromosome segregation without an intervening S phase. Exit from meiosis I is distinct from mitotic exit, in that replication origins are not licensed by...