An Alternative Beads-on-a-string Chromatin Architecture in Thermococcus Kodakarensis

Overview

Journal EMBO Rep

Specialty Molecular Biology

Date 2013 Jul 10

PMID 23835508

Citations 35

Authors

Hugo Maruyama

Janet C Harwood

Karen M Moore

Konrad Paszkiewicz

Samuel C Durley

Hisanori Fukushima

Haruyuki Atomi

Kunio Takeyasu

Nicholas A Kent

Affiliations

Soon will be listed here.

Abstract

We have applied chromatin sequencing technology to the euryarchaeon Thermococcus kodakarensis, which is known to possess histone-like proteins. We detect positioned chromatin particles of variable sizes associated with lengths of DNA differing as multiples of 30 bp (ranging from 30 bp to >450 bp) consistent with formation from dynamic polymers of the archaeal histone dimer. T. kodakarensis chromatin particles have distinctive underlying DNA sequence suggesting a genomic particle-positioning code and are excluded from gene-regulatory DNA suggesting a functional organization. Beads-on-a-string chromatin is therefore conserved between eukaryotes and archaea but can derive from deployment of histone-fold proteins in a variety of multimeric forms.

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