Samnang Tep
Overview
Explore the profile of Samnang Tep including associated specialties, affiliations and a list of published articles.
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Articles
17
Citations
179
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0
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Recent Articles
1.
Ullman J, Dick R, Linzner D, Minga T, Tep S, Satterfield T, et al.
Clin Pharmacol Ther
. 2024 Oct;
116(6):1580-1592.
PMID: 39439155
Pompe disease is a rare glycogen storage disease caused by mutations in the enzyme acid α-glucosidase (GAA) resulting in pathological accumulation of glycogen in muscle tissues leading to progressive weakness...
2.
Gaspar R, Sakuma I, Nasiri A, Hubbard B, LaMoia T, Leitner B, et al.
Am J Physiol Endocrinol Metab
. 2024 Aug;
327(4):E524-E532.
PMID: 39171753
Pompe disease is a rare genetic disorder caused by a deficiency of the enzyme acid alpha-glucosidase (GAA). This enzyme is responsible for breaking down glycogen, leading to the abnormal accumulation...
3.
Ullman J, Mellem K, Xi Y, Ramanan V, Merritt H, Choy R, et al.
Sci Transl Med
. 2024 Jan;
16(730):eadf1691.
PMID: 38232139
Glycogen synthase 1 (GYS1), the rate-limiting enzyme in muscle glycogen synthesis, plays a central role in energy homeostasis and has been proposed as a therapeutic target in multiple glycogen storage...
4.
Mihaila R, Ruhela D, Galinski B, Card A, Cancilla M, Shadel T, et al.
Mol Ther Nucleic Acids
. 2019 Apr;
16:367-377.
PMID: 30991218
Drug combinations can improve the control of diseases involving redundant and highly regulated pathways. Validating a multi-target therapy early in drug development remains difficult. Small interfering RNAs (siRNAs) are routinely...
5.
Szekrenyes A, Park S, Cosgrave E, Jones A, Haxo T, Kimzey M, et al.
Electrophoresis
. 2018 Jan;
39(7):998-1005.
PMID: 29330871
In the first part of this publication, the results from an international study evaluating the precision (i.e., repeatability and reproducibility) of N-glycosylation analysis using capillary electrophoresis of APTS-labeled N-glycans were...
6.
Szekrenyes A, Park S, Santos M, Lew C, Jones A, Haxo T, et al.
MAbs
. 2015 Oct;
8(1):56-64.
PMID: 26466659
An international team that included 20 independent laboratories from biopharmaceutical companies, universities, analytical contract laboratories and national authorities in the United States, Europe and Asia was formed to evaluate the...
7.
Reusch D, Haberger M, Maier B, Maier M, Kloseck R, Zimmermann B, et al.
MAbs
. 2014 Dec;
7(1):167-79.
PMID: 25524468
Immunoglobulin G (IgG) crystallizable fragment (Fc) glycosylation is crucial for antibody effector functions, such as antibody-dependent cell-mediated cytotoxicity, and for their pharmacokinetic and pharmacodynamics behavior. To monitor the Fc-glycosylation in...
8.
Oslob J, Johnson R, Cai H, Feng S, Hu L, Kosaka Y, et al.
ACS Med Chem Lett
. 2014 Jun;
4(1):113-7.
PMID: 24900571
Potent imidazopyridine-based inhibitors of fatty acid synthase (FASN) are described. The compounds are shown to have antiviral (HCV replicon) activities that track with their biochemical activities. The most potent analogue...
9.
Tep S, Hincapie M, Hancock W
Biotechnol Bioeng
. 2012 Jul;
109(12):3007-17.
PMID: 22752974
Within the biotechnology industry there is a continuous drive to better and more fully understand the biopharmaceutical process in order to achieve better process control. A method to monitor and...
10.
Tep S, Mihaila R, Freeman A, Pickering V, Huynh F, Tadin-Strapps M, et al.
J Lipid Res
. 2012 Feb;
53(5):859-867.
PMID: 22355095
Microsomal triglyceride transfer protein (Mtp) inhibitors represent a novel therapeutic approach to lower circulating LDL cholesterol, although therapeutic development has been hindered by the observed increase in hepatic triglycerides and...