Marija Tadin-Strapps
Overview
Explore the profile of Marija Tadin-Strapps including associated specialties, affiliations and a list of published articles.
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22
Citations
438
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Recent Articles
1.
Jiao Y, Ahmed U, Sim M, Bejar A, Zhang X, Talukder M, et al.
Mol Metab
. 2019 Apr;
24:108-119.
PMID: 30940487
Objective: Impaired expansion of peripheral fat contributes to the pathogenesis of insulin resistance and Type 2 Diabetes (T2D). We aimed to identify novel disease-gene interactions during adipocyte differentiation. Methods: Genes...
2.
McLaren D, Han S, Murphy B, Wilsie L, Stout S, Zhou H, et al.
Cell Metab
. 2018 May;
27(6):1236-1248.e6.
PMID: 29706567
Diacylglycerol acyltransferase 2 (DGAT2) catalyzes the final step in triglyceride (TG) synthesis and has been shown to play a role in regulating hepatic very-low-density lipoprotein (VLDL) production in rodents. To...
3.
Murphy B, Tadin-Strapps M, Jensen K, Mogg R, Liaw A, Herath K, et al.
Metabolism
. 2017 May;
71:202-212.
PMID: 28521874
Background: SREBP cleavage-activating protein (SCAP) is a cholesterol binding endoplasmic reticulum (ER) membrane protein that is required to activate SREBP transcription factors. SREBPs regulate genes involved in lipid biosynthesis. They...
4.
Jinn S, Drolet R, Cramer P, Wong A, Toolan D, Gretzula C, et al.
Proc Natl Acad Sci U S A
. 2017 Feb;
114(9):2389-2394.
PMID: 28193887
Parkinson disease (PD) is a neurodegenerative disorder pathologically characterized by nigrostriatal dopamine neuron loss and the postmortem presence of Lewy bodies, depositions of insoluble α-synuclein, and other proteins that likely...
5.
Jensen K, Tadin-Strapps M, Wang S, Hubert J, Kan Y, Ma Y, et al.
J Lipid Res
. 2016 Oct;
57(12):2150-2162.
PMID: 27707816
SREBP cleavage-activating protein (SCAP) is a key protein in the regulation of lipid metabolism and a potential target for treatment of dyslipidemia. SCAP is required for activation of the transcription...
6.
Khan T, Weber H, DiMuzio J, Matter A, Dogdas B, Shah T, et al.
Mol Ther Nucleic Acids
. 2016 Aug;
5(8):e342.
PMID: 27483025
Short interfering RNAs (siRNAs) are a valuable tool for gene silencing with applications in both target validation and therapeutics. Many advances have recently been made to improve potency and specificity,...
7.
Ankrom W, Wood H, Xu J, Geissler W, Bateman T, Chatterjee M, et al.
Pharmacol Res Perspect
. 2016 Mar;
4(1):e00207.
PMID: 26977298
The benefits of novel oral anticoagulants are hampered by bleeding. Since coagulation factor IX (fIX) lies upstream of fX in the coagulation cascade, and intermediate levels have been associated with...
8.
Hamza M, Kumar C, Chia S, Anandalakshmi V, Boo N, Strapps W, et al.
Atherosclerosis
. 2015 Aug;
242(2):383-95.
PMID: 26275376
The greater genomic conservation between humans and non-human primates (NHP) enables target validation studies for developing of therapeutic strategies for human diseases. Together with predicting activity and potential adverse clinical...
9.
Cai T, Wu W, Shin M, Xu Y, Jochnowitz N, Zhou Y, et al.
Blood Coagul Fibrinolysis
. 2015 Jul;
26(8):893-902.
PMID: 26192114
This report aims at exploring quantitatively the relationship between FXII inhibition and thromboprotection. FXII full and partial null in rats were established via zinc finger nuclease-mediated knockout and siRNA-mediated knockdown,...
10.
Metzger J, Tadin-Strapps M, Thankappan A, Strapps W, DiPietro M, Leander K, et al.
Thromb Haemost
. 2015 Mar;
113(6):1300-11.
PMID: 25790442
Haemophilia A and B are characterised by a life-long bleeding predisposition, and several lines of evidence suggest that risks of atherothrombotic events may also be reduced. Establishing a direct correlation...