W Michael Flanagan
Overview
Explore the profile of W Michael Flanagan including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
20
Citations
336
Followers
0
Related Specialties
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Sandhu S, McNeil C, LoRusso P, Patel M, Kabbarah O, Li C, et al.
Invest New Drugs
. 2019 Aug;
38(3):844-854.
PMID: 31385109
Background Endothelin B receptor (ETR) is involved in melanoma pathogenesis and is overexpressed in metastatic melanoma. The antibody-drug conjugate DEDN6526A targets ETR and is comprised of the humanized anti-ETR monoclonal...
2.
Mihaila R, Ruhela D, Galinski B, Card A, Cancilla M, Shadel T, et al.
Mol Ther Nucleic Acids
. 2019 Apr;
16:367-377.
PMID: 30991218
Drug combinations can improve the control of diseases involving redundant and highly regulated pathways. Validating a multi-target therapy early in drug development remains difficult. Small interfering RNAs (siRNAs) are routinely...
3.
Zewge D, Gosselin F, Kenski D, Li J, Jadhav V, Yuan Y, et al.
Bioconjug Chem
. 2014 Nov;
25(12):2222-32.
PMID: 25398098
Chemical modification of siRNA is achieved in a high-throughput manner (96-well plate format) by copper catalyzed azide-alkyne cycloadditions. This transformation can be performed in one synthetic operation at up to...
4.
Kenski D, Butora G, Willingham A, Cooper A, Fu W, Qi N, et al.
Mol Ther Nucleic Acids
. 2013 Jan;
1:e5.
PMID: 23344622
Current modifications used in small interfering RNAs (siRNAs), such as 2'-methoxy (2'-OMe) and 2'-fluoro (2'-F), improve stability, specificity or immunogenic properties but do not improve potency. These modifications were previously...
5.
Chorn G, Klein-McDowell M, Zhao L, Saunders M, Flanagan W, Willingham A, et al.
RNA
. 2012 Aug;
18(10):1796-804.
PMID: 22912485
miRNAs are ∼22-nt RNAs that bind to the Argonaute family of proteins and have important regulatory roles in plants and animals. Here, we show that miRNAs exhibit targeting activity in...
6.
Fucini R, Haringsma H, Deng P, Flanagan W, Willingham A
Nucleic Acid Ther
. 2012 Apr;
22(3):205-10.
PMID: 22519815
The immune stimulation induced by short interfering RNAs (siRNAs) has been reported to be quieted or abrogated by methoxy or fluoro modifications of the 2' position of the ribose sugar....
7.
Kenski D, Willingham A, Haringsma H, Li J, Flanagan W
Nucleic Acid Ther
. 2012 Mar;
22(2):90-5.
PMID: 22400991
Endogenous and exogenous short interfering RNAs (siRNAs) require a 5'-phosphate for loading into Ago2 and cleavage of the target mRNA. We applied a synthetic 5'-phosphate to siRNA guide strands to...
8.
Tep S, Mihaila R, Freeman A, Pickering V, Huynh F, Tadin-Strapps M, et al.
J Lipid Res
. 2012 Feb;
53(5):859-867.
PMID: 22355095
Microsomal triglyceride transfer protein (Mtp) inhibitors represent a novel therapeutic approach to lower circulating LDL cholesterol, although therapeutic development has been hindered by the observed increase in hepatic triglycerides and...
9.
Haringsma H, Li J, Soriano F, Kenski D, Flanagan W, Willingham A
Nucleic Acids Res
. 2012 Jan;
40(9):4125-36.
PMID: 22253019
While RNAi has traditionally relied on RNA duplexes, early evaluation of siRNAs demonstrated activity of the guide strand in the absence of the passenger strand. However, these single strands lacked...
10.
Butora G, Kenski D, Cooper A, Fu W, Qi N, Li J, et al.
J Am Chem Soc
. 2011 Sep;
133(42):16766-9.
PMID: 21942264
The RNA induced silencing complex (RISC) contains at its core the endonuclease Argonaute (Ago) that allows for guide strand (GS)-mediated sequence-specific cleavage of the target mRNA. Functionalization of the sugar/phosphodiester...