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Sahar Keshvari

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Articles 29
Citations 175
Followers 0
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Recent Articles
1.
Carter-Cusack D, Huang S, Keshvari S, Patkar O, Sehgal A, Allavena R, et al.
PLoS Genet . 2025 Jan; 21(1):e1011525. PMID: 39869647
Adaptation to existence outside the womb is a key event in the life of a mammal. The absence of macrophages in rats with a homozygous mutation in the colony-stimulating factor...
2.
Thierry G, Baudon E, Bijnen M, Bellomo A, Lagueyrie M, Mondor I, et al.
Immunity . 2024 Aug; 57(9):2108-2121.e6. PMID: 39089257
Unlike sessile macrophages that occupy specialized tissue niches, non-classical monocytes (NCMs)-circulating phagocytes that patrol and cleanse the luminal surface of the vascular tree-are characterized by constant movement. Here, we examined...
3.
Sajiir H, Wong K, Muller A, Keshvari S, Burr L, Aiello E, et al.
Nat Commun . 2024 May; 15(1):4527. PMID: 38811550
The IL-22RA1 receptor is highly expressed in the pancreas, and exogenous IL-22 has been shown to reduce endoplasmic reticulum and oxidative stress in human pancreatic islets and promote secretion of...
4.
Sajiir H, Keshvari S, Wong K, Borg D, Steyn F, Fercher C, et al.
Nat Commun . 2024 May; 15(1):4528. PMID: 38811532
Metabolic dysfunction-associated steatohepatitis (MASH) is the most prevalent cause of liver disease worldwide, with a single approved therapeutic. Previous research has shown that interleukin-22 (IL-22) can suppress β-cell stress, reduce...
5.
Batoon L, Keshvari S, Irvine K, Ho E, Caruso M, Patkar O, et al.
J Leukoc Biol . 2024 Mar; 116(4):753-765. PMID: 38526212
Macrophage and osteoclast proliferation, differentiation and survival are regulated by colony-stimulating factor 1 receptor (CSF1R) signaling. Osteopetrosis associated with Csf1 and Csf1r mutations has been attributed to the loss of...
6.
Keshvari S, Masson J, Ferrari-Cestari M, Bodea L, Nooru-Mohamed F, Tse B, et al.
Am J Physiol Endocrinol Metab . 2023 Dec; 326(2):E149-E165. PMID: 38117267
Macrophages regulate metabolic homeostasis in health and disease. Macrophage colony-stimulating factor (CSF1)-dependent macrophages contribute to homeostatic control of the size of the liver. This study aimed to determine the systemic...
7.
Hume D, Teakle N, Keshvari S, Irvine K
J Leukoc Biol . 2023 May; 114(5):421-433. PMID: 37167456
Macrophages are an abundant cell population in the placenta and developing embryo and appear to be involved in processes of vascularization, morphogenesis, organogenesis, and hematopoiesis. The proliferation, differentiation, and survival...
8.
Sehgal A, Carter-Cusack D, Keshvari S, Patkar O, Huang S, Summers K, et al.
Eur J Immunol . 2023 Apr; 53(8):e2250312. PMID: 37059596
Homozygous null mutation of the Csf1r gene (Csf1rko) in rats leads to the loss of most tissue macrophage populations and pleiotropic impacts on postnatal growth and organ maturation, leading to...
9.
Summers K, Bush S, Davis M, Hume D, Keshvari S, West J
Mol Genet Metab . 2023 Jan; 138(1):106979. PMID: 36630758
Fibrillin-1 is a major component of the extracellular microfibrils, where it interacts with other extracellular matrix proteins to provide elasticity to connective tissues, and regulates the bioavailability of TGFβ family...
10.
Ferrari-Cestari M, Okano S, Patel P, Horsfall L, Keshvari S, Hume D, et al.
Dig Dis . 2022 Nov; 41(3):439-446. PMID: 36327947
Background: Non-alcoholic fatty liver disease (NAFLD) is caused by ectopic fat accumulation in the liver as a consequence of metabolic perturbations associated with obesity, type 2 diabetes, dyslipidemia, and insulin...