Katharine M Irvine
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Explore the profile of Katharine M Irvine including associated specialties, affiliations and a list of published articles.
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Articles
97
Citations
2893
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Recent Articles
1.
Carter-Cusack D, Huang S, Keshvari S, Patkar O, Sehgal A, Allavena R, et al.
PLoS Genet
. 2025 Jan;
21(1):e1011525.
PMID: 39869647
Adaptation to existence outside the womb is a key event in the life of a mammal. The absence of macrophages in rats with a homozygous mutation in the colony-stimulating factor...
2.
Stables J, Pal R, Bradford B, Carter-Cusack D, Taylor I, Pridans C, et al.
Neurobiol Dis
. 2024 Nov;
203:106743.
PMID: 39581554
Amino acid substitutions in the kinase domain of the human CSF1R protein are associated with autosomal dominant adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). To model the human...
3.
Gracen L, Hartel G, Irvine K, Aikebuse M, Valery P, Powell E
Clin Gastroenterol Hepatol
. 2024 Oct;
PMID: 39447952
No abstract available.
4.
Gracen L, Aikebuse M, Sarraf B, McPhail S, Russell A, OBeirne J, et al.
Patient Prefer Adherence
. 2024 Sep;
18:1845-1855.
PMID: 39280346
Background: Although clinical guidelines endorse screening for metabolic dysfunction-associated steatotic liver disease (MASLD) with advanced fibrosis in people with type 2 diabetes (T2D), the feasibility of and barriers and considerations...
5.
Batoon L, Keshvari S, Irvine K, Ho E, Caruso M, Patkar O, et al.
J Leukoc Biol
. 2024 Mar;
116(4):753-765.
PMID: 38526212
Macrophage and osteoclast proliferation, differentiation and survival are regulated by colony-stimulating factor 1 receptor (CSF1R) signaling. Osteopetrosis associated with Csf1 and Csf1r mutations has been attributed to the loss of...
6.
Nhu N, Rahman M, Goh K, Kim S, Phan M, Peters K, et al.
Nat Commun
. 2024 Feb;
15(1):1441.
PMID: 38383596
Bacteria adapt to selective pressure in their immediate environment in multiple ways. One mechanism involves the acquisition of independent mutations that disable or modify a key pathway, providing a signature...
7.
Keshvari S, Masson J, Ferrari-Cestari M, Bodea L, Nooru-Mohamed F, Tse B, et al.
Am J Physiol Endocrinol Metab
. 2023 Dec;
326(2):E149-E165.
PMID: 38117267
Macrophages regulate metabolic homeostasis in health and disease. Macrophage colony-stimulating factor (CSF1)-dependent macrophages contribute to homeostatic control of the size of the liver. This study aimed to determine the systemic...
8.
Huang S, Carter-Cusack D, Maxwell E, Patkar O, Irvine K, Hume D
Methods Mol Biol
. 2023 Aug;
2713:99-115.
PMID: 37639117
Macrophages contribute to many aspects of development and homeostasis, innate and acquired immunity, immunopathology, and tissue repair. Every tissue contains an abundant resident macrophage population. Inflammatory stimuli promote the recruitment...
9.
Gracen L, Muthukumara W, Aikebuse M, Russell A, OBeirne J, Irvine K, et al.
Ann Hepatol
. 2023 Jul;
28(6):101142.
PMID: 37468097
Introduction And Objectives: Among people with type 2 diabetes (T2D), non-alcoholic fatty liver disease (NAFLD) is very common and has an increased risk of clinically significant liver disease. The use...
10.
Hume D, Teakle N, Keshvari S, Irvine K
J Leukoc Biol
. 2023 May;
114(5):421-433.
PMID: 37167456
Macrophages are an abundant cell population in the placenta and developing embryo and appear to be involved in processes of vascularization, morphogenesis, organogenesis, and hematopoiesis. The proliferation, differentiation, and survival...