David A Hume
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Explore the profile of David A Hume including associated specialties, affiliations and a list of published articles.
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310
Citations
23256
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Recent Articles
1.
Carter-Cusack D, Huang S, Keshvari S, Patkar O, Sehgal A, Allavena R, et al.
PLoS Genet
. 2025 Jan;
21(1):e1011525.
PMID: 39869647
Adaptation to existence outside the womb is a key event in the life of a mammal. The absence of macrophages in rats with a homozygous mutation in the colony-stimulating factor...
2.
OKeeffe M, Booker S, Walsh D, Li M, Henley C, Simoes de Oliveira L, et al.
Nat Neurosci
. 2025 Jan;
28(2):268-279.
PMID: 39762658
Brain-resident macrophages, microglia, have been proposed to have an active role in synaptic refinement and maturation, influencing plasticity and circuit-level connectivity. Here we show that several neurodevelopmental processes previously attributed...
3.
Dang T, Gillinder K, Nguyen Q, Mulay O, Vo T, Mehdi A, et al.
Clin Transl Immunology
. 2024 Dec;
13(12):e70018.
PMID: 39619016
Objectives: Langerhans cells (LCs) are epithelial antigen-presenting cells (APC) contributing to immune surveillance. LCs depend on interleukin 34 (IL34) production by epithelial cells. This study aimed to uncover mechanisms of...
4.
Stables J, Pal R, Bradford B, Carter-Cusack D, Taylor I, Pridans C, et al.
Neurobiol Dis
. 2024 Nov;
203:106743.
PMID: 39581554
Amino acid substitutions in the kinase domain of the human CSF1R protein are associated with autosomal dominant adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). To model the human...
5.
Petit M, Weber-Delacroix E, Lanthiez F, Barthelemy S, Guillou N, Firpion M, et al.
Cell Rep
. 2024 Oct;
43(10):114847.
PMID: 39395172
Tissue-resident mononuclear phagocytes (MPs) are an abundant cell population whose localization in situ reflects their identity. To enable assessment of their heterogeneity, we developed the red/green/blue (RGB)-Mac mouse based upon...
6.
Thierry G, Baudon E, Bijnen M, Bellomo A, Lagueyrie M, Mondor I, et al.
Immunity
. 2024 Aug;
57(9):2108-2121.e6.
PMID: 39089257
Unlike sessile macrophages that occupy specialized tissue niches, non-classical monocytes (NCMs)-circulating phagocytes that patrol and cleanse the luminal surface of the vascular tree-are characterized by constant movement. Here, we examined...
7.
Chadarevian J, Hasselmann J, Lahian A, Capocchi J, Escobar A, Lim T, et al.
Neuron
. 2024 Jun;
112(16):2686-2707.e8.
PMID: 38897209
Microglia replacement strategies are increasingly being considered for the treatment of primary microgliopathies like adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). However, available mouse models fail to recapitulate...
8.
Batoon L, Keshvari S, Irvine K, Ho E, Caruso M, Patkar O, et al.
J Leukoc Biol
. 2024 Mar;
116(4):753-765.
PMID: 38526212
Macrophage and osteoclast proliferation, differentiation and survival are regulated by colony-stimulating factor 1 receptor (CSF1R) signaling. Osteopetrosis associated with Csf1 and Csf1r mutations has been attributed to the loss of...
9.
OBrien C, Summers K, Martin N, Carter-Cusack D, Yang Y, Barua R, et al.
Hum Genet
. 2024 Feb;
143(3):233-261.
PMID: 38421405
The differentiation of resident intestinal macrophages from blood monocytes depends upon signals from the macrophage colony-stimulating factor receptor (CSF1R). Analysis of genome-wide association studies (GWAS) indicates that dysregulation of macrophage...
10.
Keshvari S, Masson J, Ferrari-Cestari M, Bodea L, Nooru-Mohamed F, Tse B, et al.
Am J Physiol Endocrinol Metab
. 2023 Dec;
326(2):E149-E165.
PMID: 38117267
Macrophages regulate metabolic homeostasis in health and disease. Macrophage colony-stimulating factor (CSF1)-dependent macrophages contribute to homeostatic control of the size of the liver. This study aimed to determine the systemic...