Ryuichi Okayasu
Overview
Explore the profile of Ryuichi Okayasu including associated specialties, affiliations and a list of published articles.
Author names and details appear as published. Due to indexing inconsistencies, multiple individuals may share a name, and a single author may have variations. MedLuna displays this data as publicly available, without modification or verification
Snapshot
Snapshot
Articles
75
Citations
1270
Followers
0
Related Specialties
Top 10 Co-Authors
Top 10 Co-Authors
Published In
Published In
Affiliations
Affiliations
Soon will be listed here.
Recent Articles
1.
Hirayama R, Ito A, Uzawa A, Matsumoto Y, Noguchi M, Li H, et al.
Radiat Res
. 2021 Mar;
195(5):441-451.
PMID: 33721021
We examined lethal damages of X rays induced by direct and indirect actions, in terms of double-strand break (DSB) repair susceptibility using two kinds of repair-deficient Chinese hamster ovary (CHO)...
2.
Lee Y, Okayasu R
Int J Part Ther
. 2019 Nov;
5(1):114-121.
PMID: 31773023
Heavy ion radiation therapy has been increasingly used due to several advantages over low linear energy transfer (LET) photon therapy, but further improvement of its therapeutic efficacy would be necessary....
3.
Okayasu R, Liu C
Methods Mol Biol
. 2019 Jul;
1984:31-38.
PMID: 31267417
Premature chromosome condensation (PCC) is a sensitive and unique way to detect interphase chromosome damage and its recovery in mammalian cells irradiated with ionizing radiation. In this chapter, we describe...
4.
Yasuda T, Kagawa W, Ogi T, Kato T, Suzuki T, Dohmae N, et al.
PLoS Genet
. 2018 Mar;
14(3):e1007277.
PMID: 29590107
The p300 and CBP histone acetyltransferases are recruited to DNA double-strand break (DSB) sites where they induce histone acetylation, thereby influencing the chromatin structure and DNA repair process. Whether p300/CBP...
5.
Sunada S, Hirakawa H, Fujimori A, Uesaka M, Okayasu R
Radiat Res
. 2017 Aug;
188(5):591-594.
PMID: 28829673
High-linear energy transfer (LET) heavy ions cause higher therapeutic effects than low-LET radiation due to lower dependency on oxygen concentration in tumor cell killing. The lethality after irradiation largely depends...
6.
Allen C, Hirakawa H, Nakajima N, Moore S, Nie J, Sharma N, et al.
Radiat Res
. 2017 May;
188(1):82-93.
PMID: 28535128
Genome instability is a hallmark of cancer cells and dysregulation or defects in DNA repair pathways cause genome instability and are linked to inherited cancer predisposition syndromes. Ionizing radiation can...
7.
Moeller R, Raguse M, Leuko S, Berger T, Hellweg C, Fujimori A, et al.
Astrobiology
. 2017 Feb;
17(2):101-109.
PMID: 28151691
In-depth knowledge regarding the biological effects of the radiation field in space is required for assessing the radiation risks in space. To obtain this knowledge, a set of different astrobiological...
8.
Lee Y, Sunada S, Hirakawa H, Fujimori A, Nickoloff J, Okayasu R
Mol Cancer Ther
. 2017 Jan;
16(1):16-24.
PMID: 28062703
Hsp90 inhibitors have been investigated as cancer therapeutics in monotherapy and to augment radiotherapy; however, serious adverse effects of early-generation Hsp90 inhibitors limited their development. TAS-116 is a novel Hsp90...
9.
Lee Y, Keiko Li H, Masaoka A, Sunada S, Hirakawa H, Fujimori A, et al.
Radiother Oncol
. 2016 Sep;
121(1):162-168.
PMID: 27666928
Background And Purpose: PU-H71 is a purine-scaffold Hsp90 inhibitor developed to overcome limitations of conventional Hsp90 inhibitors. This study was designed to investigate the combined effect of PU-H71 and heavy...
10.
Hirai T, Saito S, Fujimori H, Matsushita K, Nishio T, Okayasu R, et al.
Biochem Biophys Res Commun
. 2016 Jul;
478(1):234-240.
PMID: 27425251
The poly(ADP-ribose) polymerase (PARP)-1 regulates DNA damage responses and promotes base excision repair. PARP inhibitors have been shown to enhance the cytotoxicity of ionizing radiation in various cancer cells and...