Ryuichi Okayasu
Overview
Explore the profile of Ryuichi Okayasu including associated specialties, affiliations and a list of published articles.
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75
Citations
1270
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Recent Articles
11.
Sunada S, Kanai H, Lee Y, Yasuda T, Hirakawa H, Liu C, et al.
Cancer Sci
. 2016 Jun;
107(9):1250-5.
PMID: 27341700
High-linear energy transfer (LET) heavy ions have been increasingly employed as a useful alternative to conventional photon radiotherapy. As recent studies suggested that high LET radiation mainly affects the nonhomologous...
12.
Allen C, Tinganelli W, Sharma N, Nie J, Sicard C, Natale F, et al.
Front Oncol
. 2015 Dec;
5:260.
PMID: 26697402
Common cancer therapies employ chemicals or radiation that damage DNA. Cancer and normal cells respond to DNA damage by activating complex networks of DNA damage sensor, signal transducer, and effector...
13.
Fujimori H, Sato A, Kikuhara S, Wang J, Hirai T, Sasaki Y, et al.
Sci Rep
. 2015 Dec;
5:18231.
PMID: 26667181
A comprehensive genome-wide screen of radiosensitization targets in HeLa cells was performed using a shRNA-library/functional cluster analysis and DNMT3B was identified as a candidate target. DNMT3B RNAi increased the sensitivity...
14.
Fujisawa H, Nakajima N, Sunada S, Lee Y, Hirakawa H, Yajima H, et al.
Radiat Oncol
. 2015 Aug;
10:175.
PMID: 26286029
Background: High linear energy transfer (LET) radiation such as carbon ion particles is successfully used for treatment of solid tumors. The reason why high LET radiation accomplishes greater tumor-killing than...
15.
Nakajima N, Hagiwara Y, Oike T, Okayasu R, Murakami T, Nakano T, et al.
PLoS One
. 2015 Apr;
10(3):e0122582.
PMID: 25826455
The choice of DNA double strand break (DSB) repair pathway is determined at the stage of DSB end resection. Resection was proposed to control the balance between the two major...
16.
Fujisawa H, Fujimori A, Okayasu R, Uesaka M, Yajima H
Mutat Res
. 2015 Mar;
771:36-44.
PMID: 25771978
Homologous recombination (HR) is a major repair pathway for DNA double strand breaks (DSBs), and end resection, which generates a 3'-single strand DNA tail at the DSB, is an early...
17.
Hirakawa H, Fujisawa H, Masaoka A, Noguchi M, Hirayama R, Takahashi M, et al.
Cancer Med
. 2015 Jan;
4(3):426-36.
PMID: 25582113
Hsp90 inhibitors have become well-studied antitumor agents for their selective property against tumors versus normal cells. The combined treatment of Hsp90 inhibitor and conventional photon radiation also showed more effective...
18.
Xue L, Furusawa Y, Okayasu R, Miura M, Cui X, Liu C, et al.
DNA Repair (Amst)
. 2014 Dec;
25:72-83.
PMID: 25497328
DNA double strand break (DSB) repair pathway choice following ionizing radiation (IR) is currently an appealing research topic, which is still largely unclear. Our recent paper indicated that the complexity...
19.
Sato K, Imai T, Okayasu R, Shimokawa T
Radiat Res
. 2014 Sep;
182(4):408-19.
PMID: 25229975
Although it is known that cancer cells can develop radiation resistance after repeated exposures to X rays, the underlying mechanisms and characteristics of this radiation-induced resistance of cancer cells are...
20.
Takahashi M, Hirakawa H, Yajima H, Izumi-Nakajima N, Okayasu R, Fujimori A
Int J Radiat Biol
. 2014 Jun;
90(12):1125-32.
PMID: 24882391
Purpose: To obtain human glioblastoma cells A172 expressing stem cell-related protein and comparison of radiosensitivity in these cells with X-rays and carbon beam. Methods: Human monolayer-type A172 glioblastoma cells were...