Ryoichi Hirayama
Overview
Explore the profile of Ryoichi Hirayama including associated specialties, affiliations and a list of published articles.
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Articles
79
Citations
807
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Recent Articles
1.
Nakano T, Akamatsu K, Kohzaki M, Tsuda M, Hirayama R, Sassa A, et al.
Nucleic Acids Res
. 2025 Jan;
53(1.
PMID: 39797694
Ionizing radiation induces various types of DNA damage, and the reparability and lethal effects of DNA damage differ depending on its spatial density. Elucidating the structure of radiation-induced clustered DNA...
2.
Synergistic effect of Gemcitabin-loaded metal organic frameworks nanoparticles with particle therapy
Maury P, Hirayama R, Li X, Mahou P, Schanne-Klein M, Lacombe S, et al.
Int J Pharm
. 2024 Sep;
665:124721.
PMID: 39293579
Combination of nanoagents with radiations has opened up new perspectives in cancer treatment, improving both tumor diagnosis and therapeutic index. This work presents the first investigation of an innovative strategy...
3.
Shimada M, Hirayama R, Matsumoto Y
Radiat Res
. 2024 Aug;
202(4):719-725.
PMID: 39211984
Centrosomes are important organelles for cell division and genome stability. Ionizing radiation exposure efficiently induces centrosome overduplication via the disconnection of the cell and centrosome duplication cycles. Over duplicated centrosomes...
4.
Sekihara K, Himuro H, Toda S, Saito N, Hirayama R, Suganuma N, et al.
Biomedicines
. 2024 Jun;
12(6).
PMID: 38927493
Anaplastic thyroid cancer (ATC) is a rare but highly aggressive malignancy characterized by advanced disease at diagnosis and a poor prognosis. Despite multimodal therapeutic approaches that include surgery, radiotherapy, and...
5.
Sakata D, Hirayama R, Shin W, Belli M, Tabocchini M, Stewart R, et al.
Phys Med
. 2024 May;
124:103375.
PMID: 38749829
No abstract available.
6.
Takeshima T, Hirayama R, Hasegawa S
Biochem Biophys Res Commun
. 2024 May;
718:150058.
PMID: 38729076
The therapeutic efficacy of radiotherapy (RT) is primarily driven by two factors: biophysical DNA damage in cancer cells and radiation-induced anti-tumor immunity. However, Anti-tumor immune responses between X-ray RT (XRT)...
7.
Okazaki Y, Kusumoto T, Roux S, Hirayama R, Fromm M, Bazzi R, et al.
RSC Adv
. 2024 Mar;
14(14):9509-9513.
PMID: 38516151
We elucidate the decomposition mechanism of hydrogen peroxide, which is formed by water radiolysis, by gold nanoparticles (GNPs) under X-ray irradiation. The variations in yields of hydrogen peroxide generated in...
8.
Howell N, Middleton R, Sierro F, Fraser B, Wyatt N, Chacon A, et al.
Int J Radiat Oncol Biol Phys
. 2024 Mar;
120(1):229-242.
PMID: 38479560
Purpose: Neutron capture enhanced particle therapy (NCEPT) is a proposed augmentation of charged particle therapy that exploits thermal neutrons generated internally, within the treatment volume via nuclear fragmentation, to deliver...
9.
Imaizumi A, Hirayama R, Ikoma Y, Nitta N, Obata T, Hasegawa S
Cancer Sci
. 2023 Nov;
115(1):227-236.
PMID: 37994570
Charged particle beams induce various biological effects by creating high-density ionization through the deposition of energy along the beam's trajectory. Charged particle beams composed of neon ions ( Ne )...
10.
Sakata D, Hirayama R, Shin W, Belli M, Tabocchini M, Stewart R, et al.
Phys Med
. 2022 Dec;
105:102508.
PMID: 36549067
Purpose: Track structure Monte Carlo (MC) codes have achieved successful outcomes in the quantitative investigation of radiation-induced initial DNA damage. The aim of the present study is to extend a...