Ronald C Elgersma
Overview
Explore the profile of Ronald C Elgersma including associated specialties, affiliations and a list of published articles.
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11
Citations
166
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Recent Articles
1.
Elgersma R, Coumans R, Huijbregts T, Menge W, Joosten J, Spijker H, et al.
Mol Pharm
. 2015 Jan;
12(6):1813-35.
PMID: 25635711
Antibody-drug conjugates (ADCs) that are currently on the market or in clinical trials are predominantly based on two drug classes: auristatins and maytansinoids. Both are tubulin binders and block the...
2.
Elgersma R, Kroon-Batenburg L, Posthuma G, Meeldijk J, Rijkers D, Liskamp R
Eur J Med Chem
. 2014 Aug;
88:55-65.
PMID: 25087966
Peptide and protein self-assembly resulting in the formation of amyloidogenic aggregates is generally thought of as a pathological event associated with severe diseases. However, amyloid formation may also provide a...
3.
Elgersma R, van Dijk M, Dechesne A, van Nostrum C, Hennink W, Rijkers D, et al.
Org Biomol Chem
. 2009 Oct;
7(21):4517-25.
PMID: 19830304
We report on the design, synthesis, and structural analysis of cyclic oligomers with an amyloidogenic peptide sequence as the repeating unit to obtain novel self-assembling bionanomaterials. The peptide was derived...
4.
Elgersma R, Rijkers D, Liskamp R
Adv Exp Med Biol
. 2009 Apr;
611:239-40.
PMID: 19400176
No abstract available.
5.
Brouwer A, Elgersma R, Jagodzinska M, Rijkers D, Liskamp R
Bioorg Med Chem Lett
. 2007 Nov;
18(1):78-84.
PMID: 18032035
The synthesis of a new peptidomimetic structure, the alkene dipeptidosulfonamide isostere, is described. The synthesis is based on a cross metathesis reaction between two allylic building blocks, both in solution...
6.
Elgersma R, Posthuma G, Rijkers D, Liskamp R
J Pept Sci
. 2007 Sep;
13(11):709-16.
PMID: 17890652
This report reviews our approach to the design, synthesis and structural/morphological analysis of backbone-modified amylin(20-29) derivatives. Depending on the position in the peptide backbone and the type of amide bond...
7.
Elgersma R, Mulder G, Kruijtzer J, Posthuma G, Rijkers D, Liskamp R
Bioorg Med Chem Lett
. 2007 Feb;
17(7):1837-42.
PMID: 17276062
The highly amyloidogenic peptide sequence of amylin(20-29) was transformed into its corresponding peptoid and retropeptoid sequences to design a novel class of beta-sheet breaker peptides as amyloid inhibitors. This report...
8.
Elgersma R, Meijneke T, de Jong R, Brouwer A, Posthuma G, Rijkers D, et al.
Org Biomol Chem
. 2006 Sep;
4(19):3587-97.
PMID: 16990934
The incorporation of a single beta-aminoethane sulfonyl amide moiety in a highly amyloidogenic peptide sequence resulted in a complete loss of amyloid fibril formation. Instead, supramolecular folding morphologies were observed....
9.
Elgersma R, Meijneke T, Posthuma G, Rijkers D, Liskamp R
Chemistry
. 2006 Mar;
12(14):3714-25.
PMID: 16528792
Uncontrolled aggregation of proteins or polypeptides can be detrimental for normal cellular processes in healthy organisms. Proteins or polypeptides that form these amyloid deposits differ in their primary sequence but...
10.
Engel M, Yigittop H, Elgersma R, Rijkers D, Liskamp R, de Kruijff B, et al.
J Mol Biol
. 2006 Jan;
356(3):783-9.
PMID: 16403520
Amyloid deposits in the pancreatic islets of Langerhans are thought to be a main factor responsible for death of the insulin-producing islet beta-cells in type 2 diabetes. It is hypothesized...