George Posthuma
Overview
Explore the profile of George Posthuma including associated specialties, affiliations and a list of published articles.
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Articles
27
Citations
996
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0
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Recent Articles
1.
Fermie J, de Jager L, Foster H, Veenendaal T, de Heus C, van Dijk S, et al.
Cell Rep Methods
. 2022 May;
2(5):100220.
PMID: 35637912
We present a bimodal endocytic tracer, fluorescent BSA-gold (fBSA-Au), as a fiducial marker for 2D and 3D correlative light and electron microscopy (CLEM) applications. fBSA-Au consists of colloidal gold (Au)...
2.
Nalle S, Barreira da Silva R, Zhang H, Decker M, Chalouni C, Xu M, et al.
PLoS One
. 2020 Nov;
15(11):e0238484.
PMID: 33232321
Antigen cross presentation, whereby exogenous antigens are presented by MHC class I molecules to CD8+ T cells, is essential for generating adaptive immunity to pathogens and tumor cells. Following endocytosis,...
3.
Scales S, Gupta N, De Maziere A, Posthuma G, Chiu C, Pierce A, et al.
J Am Soc Nephrol
. 2020 Aug;
31(9):2044-2064.
PMID: 32764142
Background: APOL1 is found in human kidney podocytes and endothelia. Variants G1 and G2 of the gene account for the high frequency of nondiabetic CKD among African Americans. Proposed mechanisms...
4.
Honkoop H, de Bakker D, Aharonov A, Kruse F, Shakked A, Nguyen P, et al.
Elife
. 2019 Dec;
8.
PMID: 31868166
While the heart regenerates poorly in mammals, efficient heart regeneration occurs in zebrafish. Studies in zebrafish have resulted in a model in which preexisting cardiomyocytes dedifferentiate and reinitiate proliferation to...
5.
Mobius W, Posthuma G
Tissue Cell
. 2018 Sep;
57:90-102.
PMID: 30201442
Since the pioneering work of Kiyoteru Tokuyasu in the 70ths the use of thawed cryosections prepared according to the "Tokuyasu-method" for immunoelectron microscopy did not lose popularity. We owe this...
6.
Willemen H, Kavelaars A, Prado J, Maas M, Versteeg S, Nellissen L, et al.
PLoS Biol
. 2018 Feb;
16(2):e2003452.
PMID: 29444090
Chronic pain is a debilitating problem, and insights in the neurobiology of chronic pain are needed for the development of novel pain therapies. A genome-wide association study implicated the 5p15.2...
7.
Schneider V, Coorens M, Tjeerdsma-van Bokhoven J, Posthuma G, van Dijk A, Veldhuizen E, et al.
mSphere
. 2017 Nov;
2(6).
PMID: 29104934
Chicken cathelicidin-2 (CATH-2) is a broad-spectrum antimicrobial host defense peptide (HDP) that may serve as a paradigm for the development of new antimicrobial agents. While previous studies have elucidated the...
8.
Verbeek R, Siersema P, Vleggaar F, Ten Kate F, Posthuma G, Souza R, et al.
J Gastrointestin Liver Dis
. 2016 Oct;
25(3):273-82.
PMID: 27689189
Background And Aims: Inflammation plays an important role in the development of esophageal adenocarcinoma and its metaplastic precursor lesion, Barrett's esophagus. Toll-like receptor (TLR) 2 signalling and lysosomal function have...
9.
Schneider V, Coorens M, Ordonez S, Tjeerdsma-van Bokhoven J, Posthuma G, van Dijk A, et al.
Sci Rep
. 2016 Sep;
6:32948.
PMID: 27624595
Host defence peptides (HDPs) have the potential to become alternatives to conventional antibiotics in human and veterinary medicine. The HDP chicken cathelicidin-2 (CATH-2) has immunomodulatory and direct killing activities at...
10.
Bruurs L, Donker L, Zwakenberg S, Zwartkruis F, Begthel H, Knisely A, et al.
J Cell Biol
. 2015 Sep;
210(7):1055-63.
PMID: 26416959
During yeast cell polarization localization of the small GTPase, cell division control protein 42 homologue (Cdc42) is clustered to ensure the formation of a single bud. Here we show that...