Romulo J C Albuquerque
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Explore the profile of Romulo J C Albuquerque including associated specialties, affiliations and a list of published articles.
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16
Citations
1952
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Recent Articles
1.
Cho J, Bell N, Botzet G, Vora P, Fowler B, Donahue R, et al.
Transl Vis Sci Technol
. 2019 Apr;
8(2):6.
PMID: 30937216
Purpose: Chronic ocular pain is poorly understood and difficult to manage. We developed a murine model of corneal surface injury (CSI)-induced chronic ocular neuropathic pain. The study focuses on changes...
2.
Albuquerque R
Blood
. 2013 May;
121(20):4015-6.
PMID: 23682028
In this issue of Blood, Singh et al establish the existence of a new soluble isoform of vascular endothelial growth factor receptor 3 (sVEGFR-3), which is synthesized and secreted by...
3.
DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88
Tarallo V, Hirano Y, Gelfand B, Dridi S, Kerur N, Kim Y, et al.
Cell
. 2012 May;
149(4):847-59.
PMID: 22541070
Alu RNA accumulation due to DICER1 deficiency in the retinal pigmented epithelium (RPE) is implicated in geographic atrophy (GA), an advanced form of age-related macular degeneration that causes blindness in...
4.
Kleinman M, Kaneko H, Cho W, Dridi S, Fowler B, Blandford A, et al.
Mol Ther
. 2011 Oct;
20(1):101-8.
PMID: 21988875
The discovery of sequence-specific gene silencing by endogenous double-stranded RNAs (dsRNA) has propelled synthetic short-interfering RNAs (siRNAs) to the forefront of targeted pharmaceutical engineering. The first clinical trials utilized 21-nucleotide...
5.
Kaneko H, Dridi S, Tarallo V, Gelfand B, Fowler B, Cho W, et al.
Nature
. 2011 Feb;
471(7338):325-30.
PMID: 21297615
Geographic atrophy (GA), an untreatable advanced form of age-related macular degeneration, results from retinal pigmented epithelium (RPE) cell degeneration. Here we show that the microRNA (miRNA)-processing enzyme DICER1 is reduced...
6.
Shibata M, Ambati J, Shibata E, Albuquerque R, Morimoto J, Ito Y, et al.
BMC Med
. 2010 Nov;
8:69.
PMID: 21047425
Background: Cancer metastasis contributes significantly to cancer mortality and is facilitated by lymphangiogenesis and angiogenesis. A new splicing variant, endogenous soluble vascular endothelial growth factor receptor-2 (esVEGFR-2) that we recently...
7.
Albuquerque R, Hayashi T, Cho W, Kleinman M, Dridi S, Takeda A, et al.
Nat Med
. 2009 Aug;
15(9):1023-30.
PMID: 19668192
Disruption of the precise balance of positive and negative molecular regulators of blood and lymphatic vessel growth can lead to myriad diseases. Although dozens of natural inhibitors of hemangiogenesis have...
8.
Takeda A, Baffi J, Kleinman M, Cho W, Nozaki M, Yamada K, et al.
Nature
. 2009 Jun;
460(7252):225-30.
PMID: 19525930
Age-related macular degeneration (AMD), a leading cause of blindness worldwide, is as prevalent as cancer in industrialized nations. Most blindness in AMD results from invasion of the retina by choroidal...
9.
Cho W, Albuquerque R, Kleinman M, Tarallo V, Greco A, Nozaki M, et al.
Proc Natl Acad Sci U S A
. 2009 Apr;
106(17):7137-42.
PMID: 19359485
Neovascularization in response to tissue injury consists of the dual invasion of blood (hemangiogenesis) and lymphatic (lymphangiogenesis) vessels. We reported recently that 21-nt or longer small interfering RNAs (siRNAs) can...
10.
Ponticelli S, Marasco D, Tarallo V, Albuquerque R, Mitola S, Takeda A, et al.
J Biol Chem
. 2008 Oct;
283(49):34250-9.
PMID: 18922791
Vascular endothelial growth factor receptor-1 (VEGFR-1, also known as Flt-1) is involved in complex biological processes often associated to severe pathological conditions like cancer, inflammation, and metastasis formation. Consequently, the...