The Newest Member of the VEGF Family

Overview

Journal Blood

Publisher Elsevier

Specialty Hematology

Date 2013 May 18

PMID 23682028

Citations 6

Authors

Romulo J C Albuquerque

Affiliations

Soon will be listed here.

Abstract

In this issue of Blood, Singh et al establish the existence of a new soluble isoform of vascular endothelial growth factor receptor 3 (sVEGFR-3), which is synthesized and secreted by corneal epithelial cells; they show that sVEGFR-3 modulates lymphangiogenesis by impounding vascular endothelial growth factor (VEGF) C and rendering it unable to activate its cognate receptors, thereby maintaining the natural alymphatic disposition of the cornea.

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